Poor Ovarian Response: From Bench to Bedside

Dear Colleagues,

Advances observed in the field of reproductive medicine over the last four decades have led to the development of highly efficient ovarian stimulation protocols, subsequently improving reproductive outcomes. However, there is a special category of women who fail to adequately respond to controlled ovarian stimulation, also known as “poor responders”. Numerous underlying mechanisms have been proposed to be implicated in POR pathogenesis, from follicular insensitivity to exogenous gonadotrophins, down to even lifestyle parameters. Additionally, several associations and causative relationships regarding POR have been proposed, ranging from advanced maternal age and reduced ovarian reserve to genetic or even iatrogenic factors. Despite the fact that POR has been investigated for almost three decades, there is no consensus yet with regard to POR patient categorization and characterization, subsequently leading to discrepancies regarding POR management among clinicians worldwide.

Considering the significance of improving POR patient performance, we invite clinicians and reproductive scientists to contribute original research articles and reviews to this Special Issue, focusing on POR pathogenesis at the molecular, genetic and epigenetic levels. In addition, studies focusing on unveiling novel biomarkers as well as novel algorithms for accurate prediction of an expected poor ovarian response are also invited. Finally, studies investigating novel treatments and protocols aiming to improve ovarian response would be of added value.

We believe that a series of articles within this framework will make a valuable contribution toward a better understanding and managing of this multifactorial condition.

Dr. Theodoros Kalampokas
Guest Editor

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• assisted reproduction
• in vitro fertilization (IVF)
• poor ovarian response (POR)
• ovarian functionality
• ovarian aging
• ovarian stimulation
• adjuvant treatment
• biomarkers