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Biomedicines
Special Issues
Diabetes and Cancers
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Diabetes and Cancers

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 14317

Special Issue Editor

Dr. Maria Grau

E-Mail Website
Guest Editor
Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain
Interests: eHealth; preventive medicine; public health; noncommunicable diseases; empowerment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diabetes constitutes a worldwide public health problem that affected 463 million people (9.3% of the world’s population) in 2019. Recent projections suggest that this prevalence is likely to increase in the next 20 years, affecting 592 million people (10.1%) in 2035. The average life expectancy of a 50-year-old individual with diabetes is 6 years shorter than it would be without the disease. Although diabetes has been traditionally associated with cardiovascular risk, a growing body of evidence shows that this disorder leads to an increased risk of cancer. The scope of this Special Issue is to analyze the association between diabetes and cancer from an epidemiological point of view, to unravel the molecular mechanisms involved, and to describe the clinical and therapeutic implications.

Dr. Maria Grau
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetes mellitus, type 1
  • diabetes mellitus, type 2
  • neoplasms
  • epidemiology
  • treatments
  • molecular biology

Published Papers (3 papers)

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Review

16 pages, 678 KiB  
Review
Type 2 Diabetes Mellitus and Cancer: Epidemiology, Physiopathology and Prevention
by Cristina Rey-Reñones, Jose Miguel Baena-Díez, Isabel Aguilar-Palacio, Cristina Miquel and María Grau
Biomedicines 2021, 9(10), 1429; https://doi.org/10.3390/biomedicines9101429 - 9 Oct 2021
Cited by 17 | Viewed by 3339
Abstract
Individuals with type 2 diabetes mellitus are at greater risk of developing cancer and of dying from it. Both diseases are age-related, contributing to the impact of population aging on the long-term sustainability of health care systems in European Union countries. The purpose [...] Read more.
Individuals with type 2 diabetes mellitus are at greater risk of developing cancer and of dying from it. Both diseases are age-related, contributing to the impact of population aging on the long-term sustainability of health care systems in European Union countries. The purpose of this narrative review was to describe, from epidemiological, pathophysiological and preventive perspectives, the links between type 2 diabetes mellitus and the most prevalent cancers in these patients. Multiple metabolic abnormalities that may occur in type 2 diabetes mellitus, particularly obesity, could explain the increased cancer risk. In addition, the effectiveness of drugs commonly used to treat type 2 diabetes mellitus (e.g., metformin and thiazolidinediones) has been broadly evaluated in cancer prevention. Thus, a better understanding of the links between type 2 diabetes mellitus and cancer will help to identify the contributing factors and the pathophysiological pathways and to design personalized preventive strategies. The final goal is to facilitate healthy aging and the prevention of cancer and other diseases related with type 2 diabetes mellitus, which are among the main sources of disability and death in the European Union and worldwide. Full article
(This article belongs to the Special Issue Diabetes and Cancers)
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17 pages, 472 KiB  
Review
MicroRNA, Diabetes Mellitus and Colorectal Cancer
by Hsiuying Wang
Biomedicines 2020, 8(12), 530; https://doi.org/10.3390/biomedicines8120530 - 24 Nov 2020
Cited by 16 | Viewed by 3018
Abstract
Diabetes mellitus (DM) is an endocrinological disorder that is due to either the pancreas not producing enough insulin, or the body does not respond appropriately to insulin. There are many complications of DM such as retinopathy, nephropathy, and peripheral neuropathy. In addition to [...] Read more.
Diabetes mellitus (DM) is an endocrinological disorder that is due to either the pancreas not producing enough insulin, or the body does not respond appropriately to insulin. There are many complications of DM such as retinopathy, nephropathy, and peripheral neuropathy. In addition to these complications, DM was reported to be associated with different cancers. In this review, we discuss the association between DM and colorectal cancer (CRC). CRC is the third most commonly diagnosed cancer worldwide that mostly affects older people, however, its incidence and mortality are rising among young people. We discuss the relationship between DM and CRC based on their common microRNA (miRNA) biomarkers. miRNAs are non-coding RNAs playing important functions in cell differentiation, development, regulation of cell cycle, and apoptosis. miRNAs can inhibit cell proliferation and induce apoptosis in CRC cells. miRNAs also can improve glucose tolerance and insulin sensitivity. Therefore, investigating the common miRNA biomarkers of both DM and CRC can shed a light on how these two diseases are correlated and more understanding of the link between these two diseases can help the prevention of both DM and CRC. Full article
(This article belongs to the Special Issue Diabetes and Cancers)
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50 pages, 2093 KiB  
Review
Anthocyanins, Vibrant Color Pigments, and Their Role in Skin Cancer Prevention
by Zorița Diaconeasa, Ioana Știrbu, Jianbo Xiao, Nicolae Leopold, Zayde Ayvaz, Corina Danciu, Huseyin Ayvaz, Andreea Stǎnilǎ, Mǎdǎlina Nistor and Carmen Socaciu
Biomedicines 2020, 8(9), 336; https://doi.org/10.3390/biomedicines8090336 - 9 Sep 2020
Cited by 55 | Viewed by 7431
Abstract
Until today, numerous studies evaluated the topic of anthocyanins and various types of cancer, regarding the anthocyanins’ preventative and inhibitory effects, underlying molecular mechanisms, and such. However, there is no targeted review available regarding the anticarcinogenic effects of dietary anthocyanins on skin cancers. [...] Read more.
Until today, numerous studies evaluated the topic of anthocyanins and various types of cancer, regarding the anthocyanins’ preventative and inhibitory effects, underlying molecular mechanisms, and such. However, there is no targeted review available regarding the anticarcinogenic effects of dietary anthocyanins on skin cancers. If diagnosed at the early stages, the survival rate of skin cancer is quite high. Nevertheless, the metastatic form has a short prognosis. In fact, the incidence of melanoma skin cancer, the type with high mortality, has increased exponentially over the last 30 years, causing the majority of skin cancer deaths. Malignant melanoma is considered a highly destructive type of skin cancer due to its particular capacity to grow and spread faster than any other type of cancers. Plants, in general, have been used in disease treatment for a long time, and medicinal plants are commonly a part of anticancer drugs on the market. Accordingly, this work primarily aims to emphasize the most recent improvements on the anticarcinogenic effects of anthocyanins from different plant sources, with an in-depth emphasis on melanoma skin cancer. We also briefly summarized the anthocyanin chemistry, their rich dietary sources in flowers, fruits, and vegetables, as well as their associated potential health benefits. Additionally, the importance of anthocyanins in topical applications such as their use in cosmetics is also given. Full article
(This article belongs to the Special Issue Diabetes and Cancers)
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