Central Role of Mitochondrial Oxidative Stress in the Pathophysiology of Disorders
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 2252
Special Issue Editors
Interests: oxidative stress
Special Issue Information
Dear Colleagues,
Mitochondria are the main sites of cellular oxidation and energy conversion, and most cellular ATP is produced by oxidative phosphorylation. During oxidative phosphorylation, reactive oxygen species (ROS) are produced as byproducts in mitochondria, primarily by the respiratory chain complexes I and III, and are sequestered by antioxidant defenses. Mitochondrial functionality is also maintained by the so-called mitochondrial quality control, which includes processes such as mitochondrial biogenesis, dynamics, and mitophagy. Since mitochondria are considered the main source of reactive oxygen species (ROS) production in cells, impairments in bioenergetics or any mitochondrial quality control process are often accompanied by elevated ROS and oxidative damage. Therefore, mitochondrial dysfunction and ROS production are involved in the pathophysiology of primary mitochondrial diseases, neurodegenerative disorders, cardiac insufficiency, diabetes mellitus, and aging, among others. Antioxidants and modulators of mitochondrial function can reduce mitochondrial oxidative damage and are considered promising therapeutic strategies for these pathologies. In this Special Issue, we aim to contribute to a better understanding of the pathophysiology of different pathologies characterized by mitochondrial dysfunction and reveal novel therapeutic approaches for these disorders. We look forward to your contributions to this Special Issue.
Dr. Guilhian Leipnitz
Dr. André Quincozes-Santos
Guest Editors
Manuscript Submission Information
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Keywords
- mitochondrial dysfunction
- reactive oxygen species
- bioenergetics
- mitochondrial quality control
- pathologies
- protective agents
