Advanced Research of Stem Cells for Regenerative Medicine

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1739

Special Issue Editors


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Guest Editor
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy
Interests: stem cells; regenerative medicine; degenerative diseases; extracellular vesicles

Special Issue Information

Dear Colleagues,

In the field of regenerative medicine, pluripotent/multipotent stem cells, able to differentiate across germ layers, have become popular candidates to cure a plethora of diseases that are currently treated based on either palliative or symptomatic relief or by preventing their onset and progression. Over a million patients worldwide have benefited from bone marrow transplantations performed for the treatment of leukemias, anemias or immunodeficiency, and skin stem cells are used to heal severe burns, while limbal stem cells can regenerate the damaged cornea. Moreover, adult stem cells have the potential to treat a variety of degenerative diseases, as well as aging. Several clinical trials of stem cell-based therapies are underway; however, there are still several challenges to overcome before stem cells may be used in a wide range of therapeutic contexts. Therefore, understanding the factors that regulate stem cell activity and differentiation is still necessary with the hope of translating these findings into the clinic.

This Special Issue "Advanced Research of Stem Cells for Regenerative Medicine" welcomes original research and review articles on topics such as the following:

  • Molecular pathways implicated in stem cell aging and the development of novel strategies to bypass those pitfalls on their clinical uses;
  • The current progress in tissue engineering and transplantation of each type of stem cells in regenerative medicine;
  • The scaffold application and implications of nanomaterials in tissue and cell regeneration;
  • Stem cell secretome and its therapeutic potential in various diseases.

Dr. Tullia Maraldi
Dr. Martina Gatti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • regenerative therapy
  • degenerative diseases
  • aging
  • tissue engineering

Published Papers (1 paper)

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Research

12 pages, 8459 KiB  
Article
Short-Term Clinical Assessment of Treating Female Androgenetic Alopecia with Autologous Stem Cells Derived from Human Hair Follicles
by Katarzyna Krefft-Trzciniecka, Zuzanna Piętowska, Alicja Pakiet, Danuta Nowicka and Jacek C. Szepietowski
Biomedicines 2024, 12(1), 153; https://doi.org/10.3390/biomedicines12010153 - 11 Jan 2024
Viewed by 1394
Abstract
Background: Androgenetic alopecia (AGA) is the most common form of alopecia, but treatment options are limited. This study evaluated clinical improvement in hair condition in women with AGA six months after a single injection of autologous cell micrografts (ACMs) containing hair follicle stem [...] Read more.
Background: Androgenetic alopecia (AGA) is the most common form of alopecia, but treatment options are limited. This study evaluated clinical improvement in hair condition in women with AGA six months after a single injection of autologous cell micrografts (ACMs) containing hair follicle stem cells and dermal papilla cells. Methods: Twenty-three women with clinically and dermoscopy-confirmed AGA were included. Five 2.5 mm punch biopsies were taken from the skin of each patient with the Regenera device. The cell suspension was prepared with the Rigeneracons device and then injected into the hormone-dependent hairy zone of the scalp. Results: A significant improvement was observed on the visual analog scale (VAS) when comparing pre- and post-procedure photos (p < 0.001). The change in VAS scores was moderately negatively correlated with baseline ferritin concentration and positively with iron concentration. Improved outcomes were associated with higher baseline levels of sex hormone-binding globulin and 17α-hydroxyprogesterone. Neither testosterone nor DHT showed a significant correlation with VAS scores. Conclusions: The ACM procedure was shown to be both safe and effective, yielding satisfying results six months after a single treatment session. Future investigations should aim to gather evidence that enables the development of a cost-effective approach while minimizing treatment burden and costs. Full article
(This article belongs to the Special Issue Advanced Research of Stem Cells for Regenerative Medicine)
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