Chronic Pain: From Prevention to Therapeutic Strategies—Second Edition

Dear Colleagues,

Pain is a very complex and fascinating subject with three main components: physical, cognitive and emotional. These components are intrinsically connected, and their mutual influences may account for the individuality and subjectivity of pain responses.

Acute pain is usually an alert mechanism that protects the body from further tissue injury. On the other hand, chronic pain is considered a disease that is usually difficult to manage. Many chronic pain patients never achieve satisfactory pain relief. Despite the extensive investigation of pain treatment, there is still the need for research, namely in chronic pain prevention by establishing the mechanisms involved in the earlier phases of the disease. This may pass from the experimental setting to the clinical. For example, and with regard to the latter, proper postoperative pain prevention and adequate management starting in the preoperative period is imperative, and cancer management may lead to chronic pain, which is not usually prevented. Furthermore, a huge emphasis has been placed on the physical component of pain, whereas cognitive and emotional components of the pain experience are understudied, namely due to the challenges of animal pain models.

This Special Issue aims to provide the best up-to-date information on research related to prevention of chronic pain. Studies may include experimental and comprehensive reviews in this field and are expected to include the challenges related to animal research, genetic tests, novel biomarkers, predictive sensory testing, cognitive behavioral approaches for emotional component of pain, and individualization of pain patients.

Dr. Isaura Tavares
Dr. Daniel Humberto Pozza
Guest Editors

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• pain pathophysiology
• pain prevention
• predictive sensory testing
• pre- and postoperative chronic pain
• new biomarkers in pain
• pain management and novel treatments
• preemptive analgesia
• inflammatory pain