Urogenital Cancers: New Molecular and Translational Aspects on Carcinogenesis and Treatments

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 461

Special Issue Editors


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Guest Editor
IRCCS Regina Elena National Cancer Institute, Roma, Italy
Interests: genomic instability; cell cycle checkpoints; dna repair; transcriptional regulation; molecular oncology; head and neck; p53 family; mutant p53; hippo pathway
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Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy
Interests: male reproduction; testicular cancer; prostate cancer
Department of Experimental and Clinical Medicine, University “Magna Graecia” Catanzaro, 88100 Catanzaro, Italy
Interests: molecular biology; signal transduction; p75NTR-signaling; apoptosis; autophagy; EMT; renal and peritoneal fibrosis; inflammation; biological activity of natural compounds in cancer and chronic diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit a manuscript to the Special Issue “Urogenital Cancers: New Molecular and Translational Aspects on Carcinogenesis and Treatments”. Most types of urogenital cancer present with non-specific symptoms and the arrival of the diagnosis is often late.

Despite progress in the most innovative tumor therapies, the appearance of chemoresistance and metastasis represents a common cause of death in patients suffering from urological neoplasms. Therefore, it is necessary to develop new early diagnosis approaches and therapies that can improve treatment outcomes. For this purpose, it seems important to implement an understanding of the molecular mechanisms that occur in urological tumors and the research on molecular biomarkers capable of predicting tumor behavior and the risk of disease recurrence and chemoresistance.

The main aim of this Special Issue is to publish original research articles and reviews relating to urological neoplasms.

We look forward to receiving your contributions.

The aspects to address are as follows:

  • Molecular mechanisms involved in the carcinogenesis of urogenital tumors;
  • New treatment and diagnosis approaches for urogenital tumors;
  • Identification of specific molecular targets for urogenital tumors;
  • New knowledge on etiological factors (viruses, nutrition, and environmental contaminants).

Dr. Silvia Di Agostino
Dr. Vittoria Rago
Dr. Anna Perri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prostate cancer
  • bladder cancer
  • renal cell carcinoma
  • testicular cancer
  • ovarian cancer
  • endometrial cancer
  • carcinogenesis
  • biomarkers
  • early diagnosis
  • upper urinary tract tumors
  • diagnosis
  • treatment
  • environmental factors
  • diet

Published Papers (1 paper)

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Review

21 pages, 869 KiB  
Review
Recent Advancements in Research on DNA Methylation and Testicular Germ Cell Tumors: Unveiling the Intricate Relationship
by Alina-Teodora Nicu, Ileana Paula Ionel, Ileana Stoica, Liliana Burlibasa and Viorel Jinga
Biomedicines 2024, 12(5), 1041; https://doi.org/10.3390/biomedicines12051041 - 8 May 2024
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Abstract
Testicular germ cell tumors (TGCTs) are the most common type of testicular cancer, with a particularly high incidence in the 15–45-year age category. Although highly treatable, resistance to therapy sometimes occurs, with devastating consequences for the patients. Additionally, the young age at diagnosis [...] Read more.
Testicular germ cell tumors (TGCTs) are the most common type of testicular cancer, with a particularly high incidence in the 15–45-year age category. Although highly treatable, resistance to therapy sometimes occurs, with devastating consequences for the patients. Additionally, the young age at diagnosis and the treatment itself pose a great threat to patients’ fertility. Despite extensive research concerning genetic and environmental risk factors, little is known about TGCT etiology. However, epigenetics has recently come into the spotlight as a major factor in TGCT initiation, progression, and even resistance to treatment. As such, recent studies have been focusing on epigenetic mechanisms, which have revealed their potential in the development of novel, non-invasive biomarkers. As the most studied epigenetic mechanism, DNA methylation was the first revelation in this particular field, and it continues to be a main target of investigations as research into its association with TGCT has contributed to a better understanding of this type of cancer and constantly reveals novel aspects that can be exploited through clinical applications. In addition to biomarker development, DNA methylation holds potential for developing novel treatments based on DNA methyltransferase inhibitors (DNMTis) and may even be of interest for fertility management in cancer survivors. This manuscript is structured as a literature review, which comprehensively explores the pivotal role of DNA methylation in the pathogenesis, progression, and treatment resistance of TGCTs. Full article
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