Mitochondria in Human Health and Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 1123
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mitochondria, an energy center integrating with other organelles, contribute to a variety of cellular activities and stress responses through their dynamic properties such as fusion, fission and mitophagy, leading to the maintenance of cellular homeostasis. Recent advances in mitochondrial biology demonstrate that mitochondria not only act as organelles of “a cellular power plant” for ATP production to energize cellular/molecular activities of daily life, but also circulate in human peripheral blood and function as novel mediators involved in the crosstalk among different cells, tissues, and organs in physiological and pathological conditions. Increasing evidence demonstrates that mitochondria dominate the proliferation and differentiation of stem cells. Notably, mitochondria can penetrate the nuclear membrane, leading to cellular reprogramming and the generation of autologous multipotent stem cells. Interestingly, the purified mitochondria display immune modulation on the activated human T cells and the central/effector memory T cells. Therefore, targeting the mitochondrial system may facilitate the clarification of the pathogenesis of different diseases and hold tremendous therapeutic potentials to treat the inflammation-associated diseases, diabetes, autoimmune diseases, cancer, neurodegenerative diseases, and others. This Special Issue focuses on recent progress in basic research and clinical studies of mitochondria to facilitate their translational potential in clinics. Researchers and clinicians are encouraged to submit insightful reviews and research papers on the topic of mitochondria.
Dr. Yong Zhao
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondrial biology
- stem cells
- cell growth and differentiation
- immune cells
- inflammation
- autoimmunity
- diabetes
- neurodegenerative diseases
- aging
- clinical trials
