Microcirculation in Health and Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 618
Special Issue Editor
Special Issue Information
Dear Colleagues,
Microcirculation accounts for approximately 99% of all adult human blood vessels, and mediates, both structurally and functionally, between the arterial and venous parts of the cardiovascular system. It encompasses vessels narrower than 150 μm in diameter—i.e., arteries, small veins, lymphatic and arteriovenous vessels, and lymphatic and arteriovenous anastomoses—which constitute the microcirculatory unit. According to a definition based on vessel diameter and vascular muscle response to pressure difference, all vessels that are constricted by increased blood pressure form the microcirculatory unit.
Microcirculation is responsible for the exchange of nutrients and metabolites between blood and tissues, protecting the capillary network from large hydrostatic pressure fluctuations, and reducing peripheral vascular resistance. Capillaries consist of endothelial cells surrounded by pericytes and basement membranes, while arterioles have an additional thick layer of smooth muscle cells (media).
Endothelial cells, as a selective barrier between blood and surrounding tissues, are an important part of the lining of the microcirculation, and any endothelial impairment or dysfunction plays a key role in the development, progression or exacerbation of microvascular dysfunction, affecting various organ systems and their physiological processes.
Microvascular dysfunction is therefore considered to represent a generalized process that plays an important role in cardiovascular and metabolic diseases such as obesity, hypertension and diabetes, sepsis, and even cardiac transplant dysfunction. That is why this Special Issue of Biomedicines entitled “Microcirculation in Health and Diseases” will focus on the latest research on the pathogenesis, early diagnosis, or treatment of microcirculatory disorders, regardless of their location. Original research and review articles covering both conventional and innovative technologies and spanning both in vitro and in vivo studies are all welcome.
Dr. Jolanta Neubauer-Geryk
Guest Editor
Manuscript Submission Information
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Keywords
- microcirculation
- skin microcirculation
- microcirculatory disorders
- endothelial dysfunction
- therapies
- human
