Pathogenesis and Treatment of Biliopancreatic Cancer

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 564

Special Issue Editor


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Guest Editor
Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, 60126 Ancona, Italy
Interests: pancreas; biliary tract; hepatology; biliopancreatic cancer; cancer biomarkers; cancer therapy

Special Issue Information

Dear Colleagues,

Biliopancreatic cancers, including pancreatic cancers, cholangiocarcinoma, and gallbladder cancer, occur with an increasing incidence, with a large proportion accounting for fatalities related to metastatic disease.

This Special Issue on “Pathogenesis and Treatment of Biliopancreatic Cancer” aims to publish cutting-edge research on both preclinical and clinical studies on these cancers, including a comprehensive overview of tumor progression in association with the tumor microenvironment, metastatic process, cancer treatment, immune response, or drug resistance.

In the evolving landscape of oncological research, understanding the genetic and epigenetic alterations that underpin these cancers is crucial. We are particularly keen on submissions that explore the latest advancements in diagnostic tools, predictive biomarkers, and personalized treatment approaches. The intricate dance between cancer cells and the immune system, especially in the context of emerging immunotherapies, is another area of profound interest.

Review articles as well as original studies will be considered for publication. We hope that both academics and clinics working on gastrointestinal cancer will find this platform useful. We look forward to receiving exceptional submissions.

Prof. Dr. Antonio Benedetti
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biliopancreatic cancers
  • tumor microenvironment
  • metastatic process
  • immunotherapy
  • drug resistance
  • diagnostic biomarkers
  • personalized treatment
  • genetic alterations

Published Papers (1 paper)

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Research

13 pages, 3825 KiB  
Article
Prognostic Significance of the Bone Marrow-to-Aorta Uptake Ratio on 2-Deoxy-2-[18F]fluoro-d-glucose Positron Emission Tomography/Computed Tomography in Patients with Cholangiocarcinoma
by Jeong Won Lee, Ik Dong Yoo, Sun-pyo Hong, Beodeul Kang, Jung Sun Kim, Yung Kil Kim, Sang Ho Bae, Su Jin Jang and Sang Mi Lee
Biomedicines 2024, 12(5), 944; https://doi.org/10.3390/biomedicines12050944 - 24 Apr 2024
Viewed by 426
Abstract
2-Deoxy-2-[18F]fluoro-d-glucose (FDG) uptake of the reticuloendothelial system on positron emission tomography/computed tomography (PET/CT) is known to be related to systemic inflammatory response to cancer cells in patients with diverse malignancies. This retrospective study aimed to investigate whether FDG uptake [...] Read more.
2-Deoxy-2-[18F]fluoro-d-glucose (FDG) uptake of the reticuloendothelial system on positron emission tomography/computed tomography (PET/CT) is known to be related to systemic inflammatory response to cancer cells in patients with diverse malignancies. This retrospective study aimed to investigate whether FDG uptake by the reticuloendothelial system had a prognostic value in predicting progression-free survival (PFS) and overall survival (OS) in 138 cholangiocarcinoma patients. Quantifying FDG uptake of the aorta, bone marrow (BM), liver, and spleen from staging FDG PET/CT images, we found significant correlations between the BM-to-aorta uptake ratio (BAR), spleen-to-aorta uptake ratio, and BM-to-liver uptake ratio with tumor stage and serum inflammatory markers. In the multivariate survival analysis, BAR was an independent predictor of PFS (p = 0.016; hazard ratio, 2.308) and OS (p = 0.030; hazard ratio, 2.645). Patients with stages III–IV of the disease and a high BAR exhibited low 1-year PFS (35.8%) and OS (60.2%) rates, while those with stages I–II of the disease and low BAR showed robust rates of 90.0% and 96.7%, respectively. BAR measured on staging FDG PET/CT might be a potential imaging biomarker offering insights into the systemic inflammatory response and predicting prognosis in cholangiocarcinoma. This study highlights BAR as a promising, independent predictor with potential for personalized prognostication and treatment strategies. Full article
(This article belongs to the Special Issue Pathogenesis and Treatment of Biliopancreatic Cancer)
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