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Biomedicines
Special Issues
Role of Autophagy in Cancer Physiological Mechanism
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Role of Autophagy in Cancer Physiological Mechanism

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1111

Special Issue Editors

Dr. Po-Hsiang Liao

E-Mail Website
Guest Editor
Taipei Medical University Shuang-Ho Hospital, Taipei, Taiwan
Interests: m6A modification; exosome; ferroptosis; autophagy; chemoresistance
Dr. Yu-Jung Lin

E-Mail Website
Guest Editor
Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan
Interests: chemoresistance; autophagy; tumor microenvironment; apoptosis; cancer stem cell

Special Issue Information

Dear Colleagues,

Autophagy, an important physiological mechanism in recent cell research, of which there are many different types, such as mitophagy, chaperone-mediate autophagy (CMA), clockophagy, and ferritinophagy, is correlated with cell apoptosis. Different types of cancer cells usually lead to autophagy imbalance and high migration/invasion, cell metabolism changes, apoptosis, or resistance to chemotherapy. In this Special Issue, we welcome manuscripts that focus on different types of autophagy associated with cancer physiological mechanisms and the regulation of autophagy voa cancer therapy.

Dr. Po-Hsiang Liao
Dr. Yu-Jung Lin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autophagy
  • mitophagy
  • chaperone-mediate autophagy
  • clockophagy
  • ferritinophagy
  • lipophagy
  • chemoresistance
  • apoptosis
  • ferroptosis

Published Papers (1 paper)

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Research

14 pages, 4269 KiB  
Article
Mitophagy-Mediated Tumor Dormancy Protects Cancer Cells from Chemotherapy
by Yunqing Sun, Yang Chen, Zhenan Liu, Jingjing Wang, Junqiang Bai, Ruixue Du, Mingshu Long and Zhengjun Shang
Biomedicines 2024, 12(2), 305; https://doi.org/10.3390/biomedicines12020305 - 28 Jan 2024
Viewed by 912
Abstract
Despite obvious tumor shrinkage, relapse after chemotherapy remains a main cause of cancer-related mortality, indicating that a subpopulation of cancer cells acquires chemoresistance and lingers after treatment. However, the mechanism involved in the emergence of chemoresistant cells remains largely unknown. Here, we demonstrate [...] Read more.
Despite obvious tumor shrinkage, relapse after chemotherapy remains a main cause of cancer-related mortality, indicating that a subpopulation of cancer cells acquires chemoresistance and lingers after treatment. However, the mechanism involved in the emergence of chemoresistant cells remains largely unknown. Here, we demonstrate that the degradation of mitochondria via autophagy leads to a dormant state in a subpopulation of cancer cells and confers on them resistance to lethal cisplatin (DDP) exposure. The surviving DDP-resistant cells (hereafter, DRCs) have a lower metabolic rate but a stronger potential malignant potential. In the absence of DDP, these DRCs exhibit an ever-increasing self-renewal ability and heightened tumorigenicity. The combination of chloroquine and DDP exerts potent tumor-suppressive effects. In summary, our findings illuminate the mechanism between mitophagy and tumor dormancy and prove that targeting mitophagy might be a promising approach for overcoming chemoresistance in head and neck squamous cell carcinoma (HNSCC). Full article
(This article belongs to the Special Issue Role of Autophagy in Cancer Physiological Mechanism)
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