Current Perspectives on Human Papillomavirus (HPV)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Microbiology in Human Health and Disease".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1186

Special Issue Editors


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Guest Editor
1. Teaching Institute of Public Health of Split-Dalmatia County, Split, Croatia
2. University Department of Health Studies, University of Split, 21000 Split, Croatia
Interests: Human Papillomavirus (HPV)

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Guest Editor
Department of Biomedical Sciences, University North, University Centre Varaždin, Varaždin, Croatia
Interests: microbiome; microbiota; gut microbiome; vaginal microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A highly prevalent human papillomavirus (HPV) infection can be responsible for a myriad of health issues, thus unveiling the need for a comprehensive overview of the latest research developments and insights into various aspects of this viral agent. This Special Issue aims to cover the most important aspects of human papillomavirus (HPV) infections, including fundamental research, diagnostics, treatment and prevention strategies. The scope of this Special Issue includes research on the biology and molecular mechanisms of HPV, as well as studies on the clinical aspects of HPV-related diseases.

In terms of diagnostics and treatment, the Special Issue will focus on the latest advancements in diagnostic methods, particularly concerning molecular tests and their use in disease screening strategies, but also novel treatment approaches such as immunotherapy and targeted treatments. Additionally, the Special Issue will provide insights into HPV-related diseases, including the associated complications and malignancies. Likewise, prevention strategies represent an important focus of this Special Issue, including vaccination and screening as two crucial strategies for prevention and early detection, respectively.

We invite experts from the scientific fields of microbiology, virology, pathology, infectious diseases, dermatology, oncology, gynecology and urology to share their latest research results, experiences and innovations in the field of HPV research and prevention.

Dr. Vanja Kaliterna
Dr. Tomislav Meštrović
Guest Editors

Manuscript Submission Information

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Keywords

  • Human Papillomavirus (HPV)
  • molecular mechanisms
  • diagnosis
  • treatment
  • prevention
  • vaccination
  • screening
  • immunotherapy
  • cancer

Published Papers (1 paper)

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Research

13 pages, 432 KiB  
Article
Risk Factors for the Anal and Oral Human Papillomavirus (HPV) Infections among Women with Severe Cervical Lesions: A Prospective Case—Control Study
by Monika Nipčová Džundová, Borek Sehnal, Michal Zikán, Roman Kocián, Olga Dubová, Petr Hubka, Lukáš Dostálek, Pavel Kabele, Tomáš Brtnický and Jiri Slama
Biomedicines 2023, 11(12), 3183; https://doi.org/10.3390/biomedicines11123183 - 29 Nov 2023
Cited by 2 | Viewed by 926
Abstract
The carcinogenicity of HPV infection in the anogenital and oropharyngeal regions is broadly accepted. The aim of the study was to define risk factors for anal and oral HPV infections in high-risk patients with biopsy-proven severe cervical lesions (CIN2+). Altogether immunocompetent 473 females [...] Read more.
The carcinogenicity of HPV infection in the anogenital and oropharyngeal regions is broadly accepted. The aim of the study was to define risk factors for anal and oral HPV infections in high-risk patients with biopsy-proven severe cervical lesions (CIN2+). Altogether immunocompetent 473 females with CIN2+ were categorized into the study group and another 245 women into the control group. The strongest risk factor for anal HPV infection was the presence of cervical HPV infection (p < 0.001). Furthermore, ten or more lifetime sexual partners (p = 0.013), a sexual non-coital contact with the anal area (p < 0.001), and actively practicing anal-penetrative intercourse (p < 0.001) were significantly associated with anal HPV. A history of genital warts in the woman (p = 0.010) and the presence of genital warts in the male partner (p = 0.029) were found statistically significant for the risk of oral HPV infection. Our data suggest that the presence of HPV infection, especially high-risk genotypes, in one anatomical site poses the greatest risk for HPV infection in another anatomical site. The cervix is the main reservoir of infection, but the risk factors for anal and oral HPV infections are dissimilar according to different anatomical distances and more complex routes of transmission. Full article
(This article belongs to the Special Issue Current Perspectives on Human Papillomavirus (HPV))
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