Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.7
4.7
Journals
Biomedicines
Special Issues
Ischemic Stroke and Myocardial Infarction: Potential Therapeutic Targets and Translational...
share announcement

Ischemic Stroke and Myocardial Infarction: Potential Therapeutic Targets and Translational Research

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1044

Special Issue Editor

Prof. Dr. Macarena Hernández-Jiménez

E-Mail Website
Guest Editor
Department of Pharmacology and Toxicology, Faculty of Medicine, Complutense University, Madrid, Spain
Interests: stroke; cytoprotection; inflammation; pharmacology; clinical trials

Special Issue Information

Dear Colleagues,

Despite the implementation of therapies for recanalization, stroke remains the second leading cause of death and the first cause of disability in adults worldwide. Several cerebroprotective drugs are currently in clinical trials but, to date, none of them have demonstrate efficacy in large clinical trials. Therefore, the identification of new targets and the development of novel therapeutic approaches is still necessary to improve the patients’ outcomes and quality of life after suffering a stroke. The aim of this Special Issue is to present new therapeutic approaches by taking into account good research practices that guarantee animal wellbeing and provide translational results to support further clinical trials in the stroke field.

Dr. Macarena Hernández-Jiménez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • cytoprotection
  • recanalization
  • pharmacology

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

18 pages, 803 KiB  
Review
Differential Role of Factor XIII in Acute Myocardial Infarction and Ischemic Stroke
by Jan Traub, Martin S. Weber and Anna Frey
Biomedicines 2024, 12(3), 497; https://doi.org/10.3390/biomedicines12030497 - 22 Feb 2024
Viewed by 796
Abstract
Factor XIII is a transglutaminase enzyme that plays a crucial role in hemostasis and wound healing. It crosslinks fibrin strands, stabilizing clots and promoting clot resistance to fibrinolysis. Additionally, Factor XIII has been found to have multiple other functions that extend beyond coagulation, [...] Read more.
Factor XIII is a transglutaminase enzyme that plays a crucial role in hemostasis and wound healing. It crosslinks fibrin strands, stabilizing clots and promoting clot resistance to fibrinolysis. Additionally, Factor XIII has been found to have multiple other functions that extend beyond coagulation, including the regulation of inflammation and tissue repair processes. Emerging evidence suggests that Factor XIII may also have differential roles in acute myocardial infarction and ischemic stroke, two common cardiovascular events with significant morbidity and mortality. In acute myocardial infarction, Factor XIII has been implicated in promoting clot stability and reducing the risk of re-occlusion. In ischemic stroke, Factor XIII may also contribute to the pathogenesis of cerebral ischemia by promoting clot formation and exacerbating neuronal damage. Several studies have investigated the association between Factor XIII and these cardiovascular events, using various approaches such as genetic polymorphism analysis, animal models, and clinical data analysis. These studies have provided important insights into the role of Factor XIII in acute myocardial infarction and ischemic stroke, highlighting its potential as a therapeutic target for interventions aimed at improving outcomes in these conditions. In this review, we will summarize the current understanding of Factor XIII’s role in acute myocardial infarction and ischemic stroke. Full article
(This article belongs to the Special Issue Ischemic Stroke and Myocardial Infarction: Potential Therapeutic Targets and Translational Research)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop