New Insights in the Pathogenesis and Treatment of Chronic Kidney Disease and Its Complications

Dear Colleagues,

Chronic kidney disease remains a global health challenge generated by a wide variety of causes, and can present either as primitive diseases of the kidneys or have secondary involvement in various systemic diseases. Consequently, the underlying mechanisms of the tisular lesions are very different, making it more difficult to comprehensively understand the pathogenesis of primary nephropathies, an essential step for applying adequate therapeutic strategies to halt or, at least delay, the progression of chronic kidney disease. Recently, a myriad of research has underscored the roles of complement and inflammation in the occurrence of glomerular diseases, and started to decipher the mechanisms of kidney fibrosis during renal pathologies. Both of these research directions are expected to open up new insights into CKD pathogenesis and, hopefully, to provide a rationale for future effective therapeutic interventions.

Moreover, irrespective of the primary nephropathy, the main features of CKD—albuminuria and a decline in the glomerular filtration rate—were associated with a wide range of complications, from heart and brain pathologies to hematologic and mineral metabolism disorders. Despite their huge impact on the quality of life and outcome of patients with kidney diseases, the pathogenesis of the most CKD-related complications is also complex and not completely understood. Therapeutic advances have been made in this respect as well, at least in the field of cardiovascular protection, while other complications are still waiting for breakthrough discoveries.

Therefore, as a continuation of Biomedicines’ mission to provide updated information on specific topics, it is my pleasure to invite all interested researchers to share with readers their novel data in the above mentioned fields through this Special Issue.

Dr. Cristina Capusa
Guest Editor

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• complement-mediated glomerulopathies
• cardiovascular diseases
• chronic kidney disease
• mechanisms of kidney fibrosis
• mineral metabolism abnormalities
• neurologic disorders
• renal anemia
• vascular calcifications
• therapeutic strategies to reduce CKD progression