An Update on Transplantation Immunology

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1218

Special Issue Editor


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Guest Editor
Center for Vascularized Composite Allotransplantation, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Interests: mesenchymal stem cell; vascularized composite allotransplantation; transplantation immunology; cell therapy

Special Issue Information

Dear Colleagues,

The field of transplantation has made significant progress in terms of immunology, leading to better outcomes in organ and tissue transplants. This Special Issue on “An Update on Transplantation Immunology” calls for submissions showcasing the latest advancements in the field. We invite original research and review articles that explore the roles of various immunological cells and molecules in determining the fate of the transplant, including its rejection and tolerance. We also welcome contributions focusing on innovative strategies such as cell and nucleic acid therapies for immunosuppression and immune modulation. Moreover, studies utilizing advanced technologies in precision medicine and bioinformatics to optimize transplant outcomes are highly encouraged. With this collection of studies, we hope to inspire cross-disciplinary collaboration among researchers, clinicians, and specialists, fostering growth in the field and enhancing the quality of life for transplant patients. We invite authors to share their insights and discoveries to help shape the future of transplantation immunology and improve patient care.

Dr. Hui-Yun Cheng
Guest Editor

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Keywords

  • transplantation
  • immunology
  • immunosuppression
  • immunomodulation

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Published Papers (1 paper)

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Review

17 pages, 853 KiB  
Review
Heart Transplant Rejection: From the Endomyocardial Biopsy to Gene Expression Profiling
by Anca Otilia Farcas, Mihai Ciprian Stoica, Ioana Maria Maier, Adrian Cornel Maier and Anca Ileana Sin
Biomedicines 2024, 12(8), 1926; https://doi.org/10.3390/biomedicines12081926 - 22 Aug 2024
Viewed by 842
Abstract
Heart transplant prolongs life for patients with end-stage heart failure but rejection remains a complication that reduces long-term survival. The aim is to provide a comprehensive overview of the current status in HT rejection. EMB is an invasive diagnostic tool, consisting in the [...] Read more.
Heart transplant prolongs life for patients with end-stage heart failure but rejection remains a complication that reduces long-term survival. The aim is to provide a comprehensive overview of the current status in HT rejection. EMB is an invasive diagnostic tool, consisting in the sampling of a fragment of myocardial tissue from the right ventricular septum using fluoroscopic guidance. This tissue can later be subjected to histopathological, immunohistochemical or molecular analysis, providing valuable information for cardiac allograft rejection, but this procedure is not without complications. To increase the accuracy of the rejection diagnosis, EMB requires a systematic evaluation of endocardium, myocardium, interstitium and intramural vessels. There are three types of rejection: hyperacute, acute or chronic, diagnosed by the histopathological evaluation of EMB as well as by new diagnostic methods such as DSA, ddcfDNA and gene expression profiling, the last having a high negative predictive value. More than 50 years after the introduction of EMB in medical practice, it still remains the “gold standard” in monitoring rejection in HT recipients but other new, less invasive diagnostic methods reduce the number of EMBs required. Full article
(This article belongs to the Special Issue An Update on Transplantation Immunology)
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