Combined Treatments and Therapies to Cure Spinal Cord Injury
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 33586
Special Issue Editor
Interests: spinal cord injury; cellular transplantation; magnetic stimulation; spinal scar; non-invasive treatment; axonal regrowth; functional recovery; tissue repair
Special Issue Information
Dear Colleagues,
Spinal cord injury (SCI) is a rare disease of the central nervous system (CNS), most often originating from trauma following road accidents, falls or violence, causing the loss of motor, sensory and autonomic functions. To date, there is no curative treatment that can be offered to injured patients. The initial trauma induces tissue destruction, the rupture of blood vessels and axons and death of neurons and oligodendrocytes at the site of injury, these events leading to myelin release and inflammation. This reactionary cascade leads to the formation of a spinal scar composed of astrocytes, microglial cells and macrophages, fibroblasts and cystic cavities. This scar has a dual role: beneficial in delimiting the lesioned area, and deleterious in preventing axonal regrowth; thus, leading to a loss of connection between the CNS and the periphery. Many treatments have been tested to allow tissue and functional recovery after SCI. However, the complexity of the injury suggests that a single treatment is not sufficient to induce real benefits in humans. Therefore, it is thought that only the use of combination therapies would be effective in promoting recovery after SCI, although the ideal combination remains to be determined.
We cordially invite you to contribute to the Special Issue entitled “Combined Treatments and Therapies to Cure Spinal Cord Injury”. Our aim is to provide most relevant information concerning innovative treatment modalities and their combinations as potential innovative treatments after SCI. Original investigations and review articles are both welcome.
Dr. Nicolas Guerout
Guest Editor
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Keywords
- spinal cord injury
- tissue repair
- functional recovery
- combined treatments
- innovative therapy
- glial scar
- inflammation
- axonal regrowth
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