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Biomedicines
Special Issues
Lipid Metabolism: Functions, Biomarkers and Therapies
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Lipid Metabolism: Functions, Biomarkers and Therapies

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Gene and Cell Therapy".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 4512

Special Issue Editors

Dr. Joan Carles Escolà-Gil

E-Mail Website
Guest Editor
Institut d’Investigacions Biomèdiques (IIB) Sant Pau, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain
Interests: atherosclerosis; cholesterol; genetically-modified mice; HDL; lipoproteins
Special Issues, Collections and Topics in MDPI journals
Dr. Noemí Rotllan

E-Mail Website
Guest Editor
Institut dInvestigació Biomèdica Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain
Interests: atherosclerosis; miRNAs; lipid metabolism; therapeutic approaches
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce our support and editorial responsibility for a new Special Issue of Biomedicines, entitled “Lipid Metabolism: Functions, Biomarkers and Therapies”. Advances in functional genomics, metabolomics, lipidomics, etc., have uncovered new ways to control mechanisms mediating lipid metabolism. MicroRNAs (miRNAs) are a family of important transcriptional and post-transcriptional regulators of the target genes that codify the proteins that are involved in multiple lipid metabolism pathways, thereby influencing cholesterol and fatty acid homeostasis. These miRNAs have emerged as promising therapeutic targets for the treatment of lipid-related metabolic alterations in diseases such as atherosclerosis, diabetes, obesity, and liver disease. Most of these miRNAs act at an intracellular level, but they can be also transported in biofluids and used as potential biomarkers of lipid metabolic alterations.

This Special Issue aims to publish timely and informative findings on lipid and lipoprotein metabolism. Original research articles and reviews are welcome.

Dr. Joan Carles Escolà-Gil
Dr. Noemí Rotllan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • cholesterol
  • fatty acid
  • lipids
  • metabolism
  • microRNA
  • therapies

Published Papers (3 papers)

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Research

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14 pages, 2189 KiB  
Article
Circulating miRNA Correlates with Lipid Profile and Disease Activity in Psoriatic Arthritis, Rheumatoid Arthritis, and Ankylosing Spondylitis Patients
by Krzysztof Bonek, Ewa Kuca Warnawin, Anna Kornatka, Magdalena Plebańczyk, Tomasz Burakowski, Włodzimierz Maśliński, Małgorzata Wisłowska, Piotr Głuszko and Marzena Ciechomska
Biomedicines 2022, 10(4), 893; https://doi.org/10.3390/biomedicines10040893 - 13 Apr 2022
Cited by 5 | Viewed by 1737
Abstract
This study aimed to investigate the associations of microRNA (miRs) signatures with cytokines, serum lipids, and disease activity in patients with psoriatic arthritis (PsA), ankylosing spondylitis (AS), and rheumatoid arthritis (RA). In total, 65 patients (PsA n = 25, AS n = 25, [...] Read more.
This study aimed to investigate the associations of microRNA (miRs) signatures with cytokines, serum lipids, and disease activity in patients with psoriatic arthritis (PsA), ankylosing spondylitis (AS), and rheumatoid arthritis (RA). In total, 65 patients (PsA n = 25, AS n = 25, RA n = 15) and 25 healthy controls (HC) were enrolled into the study. The expression of miR-223-5p, miR-92b-3p, miR-485-3p, miR-10b-5p, let-7d-5p, miR-26a-2-3p, miR-146b-3p, and cytokines levels were measured in sera. DIANA-mirPath analysis was used to predict pathways targeted by the dysregulated miRs. Disease activity scores were calculated. Lipid profile, uric acid, glucose level, and C-reactive protein (CRP) concentrations were determined in the blood. Based on lipid profiles, the PsA group had hypertriglyceridaemia, and RA patients revealed mixed dyslipidaemia, while in AS, no specific changes were found. miR expression analysis revealed upregulation of miR-26a-2-3p and miR-10b-5p in PsA, miR-485-3p in AS, and let-7d-5p in RA. Several correlations between disease activity indexes, metabolites levels, and expression of miRs were observed in PsA, RA, and AS patients. Finally, in ROC analysis, miR-26a-2-3p/miR-485-3p, and let-7d-5p/miR-146b-3p tandems revealed high sensitivity and specificity in distinguishing between PsA, AS, and RA. Our study illustrates the superiority of miR expressions in distinguishing between RA, PsA, and AS. In PsA, a unique regulatory pathway exists through miR-26a-2-3p, miR-223-5p, miR-10b-5p, and miR-92b-3p that converges proatherogenic metabolism and disease activity. Full article
(This article belongs to the Special Issue Lipid Metabolism: Functions, Biomarkers and Therapies)
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Review

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20 pages, 5021 KiB  
Review
Protective Effects of High-Density Lipoprotein on Cancer Risk: Focus on Multiple Myeloma
by Alessandro Allegra, Giuseppe Murdaca, Giuseppe Mirabile and Sebastiano Gangemi
Biomedicines 2024, 12(3), 514; https://doi.org/10.3390/biomedicines12030514 - 24 Feb 2024
Viewed by 783
Abstract
Lipid metabolism is intrinsically linked to tumorigenesis. And one of the most important characteristics of cancer is the modification of lipid metabolism and its correlation with oncogenic signaling pathways within the tumors. Because lipids function as signaling molecules, membrane structures, and energy sources, [...] Read more.
Lipid metabolism is intrinsically linked to tumorigenesis. And one of the most important characteristics of cancer is the modification of lipid metabolism and its correlation with oncogenic signaling pathways within the tumors. Because lipids function as signaling molecules, membrane structures, and energy sources, lipids are essential to the development of cancer. Above all, the proper immune response of tumor cells depends on the control of lipid metabolism. Changes in metabolism can modify systems that regulate carcinogenesis, such as inflammation, oxidative stress, and angiogenesis. The dependence of various malignancies on lipid metabolism varies. This review delves into the modifications to lipid metabolism that take place in cancer, specifically focusing on multiple myeloma. The review illustrates how changes in different lipid pathways impact the growth, survival, and drug-responsiveness of multiple myeloma cells, in addition to their interactions with other cells within the tumor microenvironment. The phenotype of malignant plasma cells can be affected by lipid vulnerabilities, and these findings offer a new avenue for understanding this process. Additionally, they identify novel druggable pathways that have a major bearing on multiple myeloma care. Full article
(This article belongs to the Special Issue Lipid Metabolism: Functions, Biomarkers and Therapies)
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13 pages, 1241 KiB  
Review
MicroRNA Profile, Putative Diagnostic Biomarkers and RNA-Based Therapies in the Inherited Lipid Storage Disease Niemann-Pick Type C
by Marisa Encarnação, Hugo David, Maria Francisca Coutinho, Luciana Moreira and Sandra Alves
Biomedicines 2023, 11(10), 2615; https://doi.org/10.3390/biomedicines11102615 - 23 Sep 2023
Viewed by 1089
Abstract
Lipids are essential for cellular function and are tightly controlled at the transcriptional and post-transcriptional levels. Dysregulation of these pathways is associated with vascular diseases, diabetes, cancer, and several inherited metabolic disorders. MicroRNAs (miRNAs), in particular, are a family of post-transcriptional gene repressors [...] Read more.
Lipids are essential for cellular function and are tightly controlled at the transcriptional and post-transcriptional levels. Dysregulation of these pathways is associated with vascular diseases, diabetes, cancer, and several inherited metabolic disorders. MicroRNAs (miRNAs), in particular, are a family of post-transcriptional gene repressors associated with the regulation of many genes that encode proteins involved in multiple lipid metabolism pathways, thereby influencing their homeostasis. Thus, this class of non-coding RNAs (ncRNAs) has emerged as a promising therapeutic target for the treatment of lipid-related metabolic alterations. Most of these miRNAs act at an intracellular level, but in the past few years, a role for miRNAs as intercellular signaling molecules has also been uncovered since they can be transported in bodily fluids and used as potential biomarkers of lipid metabolic alterations. In this review, we point out the current knowledge on the miRNA signature in a lysosomal storage disorder associated with lipid dysfunction, Niemann-Pick type C, and discuss the potential use of miRNAs as biomarkers and therapeutic targets for RNA-based therapies. Full article
(This article belongs to the Special Issue Lipid Metabolism: Functions, Biomarkers and Therapies)
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