New Insights into Diagnostic and Prognostic Biomarkers of Amyotrophic Lateral Sclerosis: Must Innovative Findings Come from New Targets?
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biomarkers".
Deadline for manuscript submissions: closed (15 June 2024) | Viewed by 1491
Special Issue Editor
Special Issue Information
Dear Colleagues,
Amyotrophic lateral sclerosis (ALS) remains a hot topic in the field of neurological research as no diagnosis, prognosis, and efficient treatment are available today. Although progress in exploratory methods is revolutionizing the research, especially on biomarkers, and the diversity of experimental models offers new opportunities to depict ALS, the topic of whether knowledge improvement must mandatorily come from rupture innovation is still up for debate. More specifically, we can suspect that the deep exploration of some targets has been abandoned to move toward more attractive and spectacular ones. Similarly, basic exploration methods for biomarkers have been replaced by omics, and standard data analysis has been replaced by artificial intelligence. However, research on more powerful and ambitious approaches may hide relevant findings based on more standard methods.
This Special Issue of Biomolecules will focus on the most recent advances in relation to 1) well-known targets described for many years but explored in different ways (SOD1, TDP-43, etc.), 2) isolated biomarkers provided by both targeted methods and large omics strategies, 3) promising results from standard experimental models, even if old and questionable, and 4) the mode effect via the exploration of ways largely described in several neurological diseases but rarely in ALS.
Both research (in particular) and review articles proposing novelties or overviews, respectively, are welcome.
Dr. Hélène Blasco
Guest Editor
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Keywords
- biomarkers
- omics
- animal models
- innovation
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