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Journals
Biomolecules
Special Issues
Advances in Liver X Receptors
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Advances in Liver X Receptors

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1682

Special Issue Editors

Dr. Kaori Endo-Umeda

E-Mail Website
Guest Editor
Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
Interests: nuclear receptors; lipid metabolism; cholesterol; inflammation; tissue-resident immune cells; non-alcohol steatohepatitis; atherosclerosis; tumor immunity
Prof. Dr. Makoto Makishima

E-Mail Website
Guest Editor
Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
Interests: regulation of lipid metabolism and immunity by nuclear receptors in the liver and intestine; molecular basis of function-selective nuclear receptor ligands and application to drug discovery; regulation of xenobiotic metabolisms and their relationship to human disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The nuclear receptor liver X receptors α (LXRα) and LXRβ are transcription factors activated by oxysterols and regulate cholesterol homeostasis. LXRs also play important roles in the regulation of innate and adaptive immune responses in leukocytes. Thus, LXRs could be therapeutic targets for various diseases such as cardiovascular diseases, non-alcoholic steatohepatitis, cancer, infectious diseases and autoimmune diseases. However, their cell-type specific target genes and functions have not completely been explored.

This Special Issue welcomes original articles and reviews focused on the recent advances in the regulation of metabolism and immunity by LXRs in physiological and disease conditions. We also welcome articles regarding other novel LXR functions and the development of novel LXR ligands for protection and therapy in relation to disease treatment.

We look forward to reading your contributions.

Dr. Kaori Endo-Umeda
Prof. Dr. Makoto Makishima
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver X receptor
  • lipid metabolism
  • cholesterol
  • oxysterol
  • atherosclerosis
  • non-alcoholic steatohepatitis
  • inflammation
  • tumor immunity

Published Papers (1 paper)

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Review

16 pages, 1606 KiB  
Review
Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers
by Ning Han, Man Yuan, Libo Yan and Hong Tang
Biomolecules 2023, 13(8), 1184; https://doi.org/10.3390/biom13081184 - 28 Jul 2023
Cited by 2 | Viewed by 1357
Abstract
Liver X receptor α (LXRα), a member of the nuclear receptor superfamily, is identified as a protein activated by ligands that interacts with the promoters of specific genes. It regulates cholesterol, bile acid, and lipid metabolism in normal physiological processes, and it participates [...] Read more.
Liver X receptor α (LXRα), a member of the nuclear receptor superfamily, is identified as a protein activated by ligands that interacts with the promoters of specific genes. It regulates cholesterol, bile acid, and lipid metabolism in normal physiological processes, and it participates in the development of some related diseases. However, many studies have demonstrated that LXRα is also involved in regulating numerous human malignancies. Aberrant LXRα expression is emerging as a fundamental and pivotal factor in cancer cell proliferation, invasion, apoptosis, and metastasis. Herein, we outline the expression levels of LXRα between tumor tissues and normal tissues via the Oncomine and Tumor Immune Estimation Resource (TIMER) 2.0 databases; summarize emerging insights into the roles of LXRα in the development, progression, and treatment of different human cancers and their diversified mechanisms; and highlight that LXRα can be a biomarker and therapeutic target in diverse cancers. Full article
(This article belongs to the Special Issue Advances in Liver X Receptors)
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