DNA Damage and DNA Repair in Cancer
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Nucleic Acids".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 11677
Special Issue Editors
Interests: DNA damage; DNA repair; cancer; radiation therapy; bioinformatics
Interests: radiation-induced chromosome aberrations; DNA repair; hadrontherapy; radiosensitization and radioprotection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue focuses on the most recent insights on the role(s) that DNA damage and repair have on cancer development and therapy. The maintenance of DNA integrity and the fidelity of the repair of exogenous as well as endogenous DNA damage as the main barrier against cellular transformation is a tenet in carcinogenesis. Cancerous cells are commonly viewed as lacking repair proficiency or harbouring defective biomolecular pathways compared to non-cancer cells. At the same time, many forms of anticancer strategies rely on further impairing cancer cell repair ability. However, how the latter is achieved varies according to whether the anticancer agent is a chemical or ionizing radiation, for example. Understanding how cancer may continue to progress in the face of incorrect lesion restitution and immune system evasion is arguably a crucial target of interdisciplinary research. Moreover, the complex interactions that take place within the microenvironment in which the initiating steps of transformation occur and possible systemic effects play a pivotal role in establishing features, such as resilience to chemo/radiotherapy, as well as proneness to acquire an aggressive phenotype.
Therefore, in this Special Issue, we welcome original basic research carried out by pre-clinical in vitro and/or in vivo approaches, as well as up-to-date reviews on these topics, with special emphasis on the novel frontiers in the fields of radiotherapy, immunotherapy and anticancer molecular targets.
Prof. Dr. Alexandros Georgakilas
Prof. Dr. Lorenzo Manti
Guest Editors
Manuscript Submission Information
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Keywords
- DNA damage
- DNA repair
- cancer
- therapy
- radiation biology
- systems biology
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