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Biomolecules
Special Issues
Molecular Interventions in Ocular Disorders
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Molecular Interventions in Ocular Disorders

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1843

Special Issue Editor

Prof. Dr. Jaeyong Kim

E-Mail Website
Guest Editor
Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro, Songpa-Gu, Seoul 05505, Republic of Korea
Interests: cataract; femtosecond laser-assisted cataract surgery; corneal disease; corneal transplantation; presbyopia; IPL-dry eye disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue ‘Molecular Interventions in Ocular Disorders’ aims to provide a comprehensive overview of the recent developments, progressions, and innovations in ophthalmology. It will focus on the latest therapeutic approaches for ocular disorders, ranging from traditional medical therapy to emerging modalities such as gene therapy, regenerative medicine, targeted therapies, and customized treatment strategies. It will also explore the recent advancements in surgical techniques, including minimally invasive surgery and advanced intraocular devices. Furthermore, this Special Issue will discuss innovations that can promote surgical precision, improve patient outcomes, and minimize post-operative complications, thereby enhancing the quality of life of patients with ocular disorders.

Prof. Dr. Jaeyong Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular interventions
  • innovative therapies
  • surgical techniques
  • gene therapy
  • regenerative medicine
  • targeted therapies
  • customized treatment

Published Papers (1 paper)

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Research

15 pages, 4033 KiB  
Article
Effect of Topical Programmed Death-Ligand1 on Corneal Epithelium in Dry Eye Mouse
by Ko Eun Lee, Seheon Oh, Basanta Bhujel, Chang Min Kim, Hun Lee, Jin Hyoung Park and Jae Yong Kim
Biomolecules 2024, 14(1), 68; https://doi.org/10.3390/biom14010068 - 4 Jan 2024
Viewed by 1508
Abstract
Dry eye disease (DED) is a growing health concern that impacts millions of individuals every year, and is associated with corneal injury, excessive oxidative stress and inflammation. Current therapeutic strategies, including artificial tears and anti-inflammatory agents, are unable to achieve a permanent clinical [...] Read more.
Dry eye disease (DED) is a growing health concern that impacts millions of individuals every year, and is associated with corneal injury, excessive oxidative stress and inflammation. Current therapeutic strategies, including artificial tears and anti-inflammatory agents, are unable to achieve a permanent clinical cure due to their temporary nature or adverse side effects. Therefore, here, we investigated the effectiveness of the topical administration of programmed death-ligand 1 (PD-L1) in the mouse model of DED. The model was generated in C57BL/6 mice by excising the extra orbital lacrimal gland and causing desiccation stress with scopolamine injections. Subsequently, either phosphate-buffered saline (3 µL/eye) or PD-L1 (0.5 µg/mL) was topically administered for 10 days. Tear volume was evaluated with phenol red thread, and corneal fluorescein staining was observed to quantify the corneal epithelial defect. Corneas were collected for histological analysis, and the expression levels of inflammatory signaling proteins such as CD4, CD3e, IL-17, IL-1β, pIkB-α, pNF-kB and pERK1/2 were assessed through immunofluorescence and Western blot techniques. Our results demonstrate that desiccating stress-induced corneal epithelial defect and tear secretion were significantly improved by topical PD-L1 and could reduce corneal CD4+ T cell infiltration, inflammation and apoptosis in a DED mouse model by downregulating IL-17 production and ERK1/2-NFkB pathways. Full article
(This article belongs to the Special Issue Molecular Interventions in Ocular Disorders)
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