PARPs in Cell Death and PARP Inhibitors in Cancers

Dear Colleagues,

Poly (ADP-ribose) polymerases (PARPs) are a family of related enzymes that participate in many cellular processes such as DNA repair, genomic stability, transcription, replication, mitosis, cell growth, and programmed cell death. Combined with the concept of synthetic lethality, PARP inhibitors are developed to inhibit the growth of cancer cells and kill them. At present, four PARP inhibitors have been approved by the United States Food and Drug Administration for the treatment of ovarian cancer, breast cancer, pancreatic cancer, and other cancers.

Nevertheless, the process in which PARP participates in cells and the mechanism of PARP inhibitors in cancers still need to be constantly explored to develop more application value for PARP and PARP inhibitors.

This Special Issue will include papers about the role of PARPs in cell death and the mechanism and application of PARP inhibitors in cancers. Papers can be research articles or review articles. We look forward to your contribution.

Dr. María Isabel Rodríguez
Prof. Dr. Josefa León
Guest Editors

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• PARPs
• PARP inhibitors
• cancers
• cell death
• DNA repair