The Physiological and Pathological New Function of Mitochondrial ROS and Intraorganellar Cross-Talks Part II
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Structure and Dynamics".
Deadline for manuscript submissions: closed (3 June 2024) | Viewed by 6463
Special Issue Editors
Interests: mitochondria; oxidative stress; cell signaling; mitochondrial DNA; mitochondrial RNA; lipid peroxidation; hair; neuron; aging
Special Issues, Collections and Topics in MDPI journals
Interests: Nrf2; ATF4; mito-nuclear communication; mitochondrial antioxidant; Keap1; anti-aging
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Thijsj G. Rttema described “Mitochondria in the second act”, citing Pittis and Gabaldón (page 101), who provide evidence that the host cell from which eukaryotes evolved was already genetically chimaeric before the mitochondrial symbiosis, suggesting that mitochondria evolved later in eukaryotic evolution than was previously presumed (https://www.nature.com/articles/nature16876; Nature volume 531, pages 39–40 (03 March 2016)). This means that when mitochondria are established, it is possible to commence cross-talk between mitochondria and other organelles. This is one of the newest topics causing a reconsidering of intracellular organelle cross-talk. Majima et al. were the first to report that reactive oxygen species (ROS) generated from mitochondria promote apoptosis (Majima et al., J Biol. Chem. 1998), while Itoh et al. described the function of the Nrf2-Keap1 intercellular signal for the first time (Itoh et al., Biochem. Biophys. Res. Commun. 1997, Itoh et al., Genes Dev. 1999). A recent study has described that ROS generated from mitochondria initiate cellular transduction in cytosol (Indo et al. Handb Exp Pharmacol. 2017). In this Special Issue, the further roles of mitochondria-generated ROS and the subsequent intraorganellar cross-talks, signal exchange, and protein import, important in retaining cellular networks and homeostasis, will be discussed. We aim to establish a new world of cellular functions.
Prof. Dr. Hideyuki J. Majima
Prof. Dr. Ken Itoh
Guest Editors
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Keywords
- mitochondrial ROS
- cellular signaling
- intraorganellar cross-talks
- mito-nuclear communication
- mitochondrial antioxidant
- aging
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