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8.3
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Biomolecules
Special Issues
Molecular Mechanisms Underlying Cell Adhesion and Migration
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Molecular Mechanisms Underlying Cell Adhesion and Migration

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2948

Special Issue Editor

Dr. Kun Ling

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Mayo Clinic, Jacksonville, FL, USA
Interests: phosphoinositides signaling; cell migration; cell adhesions; cancer metastasis; vesicular trafficking; primary cilia; ciliopathies

Special Issue Information

Dear Colleagues,

Cell adhesion and cell migration are essential biological processes for multicellular organisms. The spatiotemporally-controlled fine coordination of cell adhesion and migration is key to well-organized organogenesis and embryogenesis. This is also true for maintaining tissue/organ homeostasis and normal functions, such as immune response, tissue repair, and wound healing. Abnormal cell adhesion and migration lead to various diseases, such as cancer metastasis, thrombosis, inflammation, etc. Numerous molecules participate in cell adhesion and migration. In different cell types, molecular mechanisms driving and regulating cell adhesion and cell migration are often different. Understanding how cell adhesion and migration are achieved precisely under different biological scenarios is an ongoing challenge. This Special Issue is open to comprehensive reviews, original research papers, and high-quality communications to discuss the molecular mechanisms underlying cell adhesion and migration during normal development and diseases. In particular, studies in the fields of molecular structure and dynamics, molecular biophysics, and cellular biochemistry are welcome.

Dr. Kun Ling
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell–cell adhesion
  • cell–matrix adhesion
  • cell migration
  • cytoskeleton reorganization

Published Papers (2 papers)

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Review

13 pages, 1417 KiB  
Review
Phosphoinositide Signaling in Immune Cell Migration
by Ruchi Kakar, Chinmoy Ghosh and Yue Sun
Biomolecules 2023, 13(12), 1705; https://doi.org/10.3390/biom13121705 - 24 Nov 2023
Viewed by 1006
Abstract
In response to different immune challenges, immune cells migrate to specific sites in the body, where they perform their functions such as defense against infection, inflammation regulation, antigen recognition, and immune surveillance. Therefore, the migration ability is a fundamental aspect of immune cell [...] Read more.
In response to different immune challenges, immune cells migrate to specific sites in the body, where they perform their functions such as defense against infection, inflammation regulation, antigen recognition, and immune surveillance. Therefore, the migration ability is a fundamental aspect of immune cell function. Phosphoinositide signaling plays critical roles in modulating immune cell migration by controlling cell polarization, cytoskeletal rearrangement, protrusion formation, and uropod contraction. Upon chemoattractant stimulation, specific phosphoinositide kinases and phosphatases control the local phosphoinositide levels to establish polarized phosphoinositide distribution, which recruits phosphoinositide effectors to distinct subcellular locations to facilitate cell migration. In this Special Issue of “Molecular Mechanisms Underlying Cell Adhesion and Migration”, we discuss the significance of phosphoinositide production and conversion by phosphoinositide kinases and phosphatases in the migration of different types of immune cells. Full article
(This article belongs to the Special Issue Molecular Mechanisms Underlying Cell Adhesion and Migration)
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13 pages, 1349 KiB  
Review
Regulation of Cell Adhesion and Migration via Microtubule Cytoskeleton Organization, Cell Polarity, and Phosphoinositide Signaling
by Narendra Thapa, Tianmu Wen, Vincent L. Cryns and Richard A. Anderson
Biomolecules 2023, 13(10), 1430; https://doi.org/10.3390/biom13101430 - 22 Sep 2023
Cited by 2 | Viewed by 1550
Abstract
The capacity for cancer cells to metastasize to distant organs depends on their ability to execute the carefully choreographed processes of cell adhesion and migration. As most human cancers are of epithelial origin (carcinoma), the transcriptional downregulation of adherent/tight junction proteins (e.g., E-cadherin, [...] Read more.
The capacity for cancer cells to metastasize to distant organs depends on their ability to execute the carefully choreographed processes of cell adhesion and migration. As most human cancers are of epithelial origin (carcinoma), the transcriptional downregulation of adherent/tight junction proteins (e.g., E-cadherin, Claudin and Occludin) with the concomitant gain of adhesive and migratory phenotypes has been extensively studied. Most research and reviews on cell adhesion and migration focus on the actin cytoskeleton and its reorganization. However, metastasizing cancer cells undergo the extensive reorganization of their cytoskeletal system, specifically in originating/nucleation sites of microtubules and their orientation (e.g., from non-centrosomal to centrosomal microtubule organizing centers). The precise mechanisms by which the spatial and temporal reorganization of microtubules are linked functionally with the acquisition of an adhesive and migratory phenotype as epithelial cells reversibly transition into mesenchymal cells during metastasis remains poorly understood. In this Special Issue of “Molecular Mechanisms Underlying Cell Adhesion and Migration”, we highlight cell adhesion and migration from the perspectives of microtubule cytoskeletal reorganization, cell polarity and phosphoinositide signaling. Full article
(This article belongs to the Special Issue Molecular Mechanisms Underlying Cell Adhesion and Migration)
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