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8.3
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Journals
Biomolecules
Special Issues
Advances in Melanoma Targeted Therapy
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Advances in Melanoma Targeted Therapy

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 20 August 2024 | Viewed by 4119

Special Issue Editor

Dr. Dmitriy Minond

E-Mail Website
Guest Editor
College of Pharmacy and Rumbaugh Goodwin Institute for Cancer Research, Nova Southeastern University, Fort Lauderdale, FL 33314, USA
Interests: drug screening; anti-cancer drug design and discovery; drug target development; small-molecule drug discovery; cancer biology

Special Issue Information

Dear Colleagues,

Despite the advances in melanoma therapy in recent years, there is still a pressing need for novel approaches and targets. The current treatments for melanoma have many limitations, including low response rates, a lack of targeted therapies for “triple-wide type” and NRAS mutant melanoma, and drug resistance, all of which necessitate the discovery of new agents and targets for melanoma.

In this Special Issue, we aim to publish the most recent developments in targeted therapies for melanoma.

We would like to invite you to contribute research and review manuscripts that report on novel molecules (small and large) that are active against melanoma and novel targets.

We look forward to reading your contributions.

Dr. Dmitriy Minond
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • melanoma
  • drug discovery
  • new targets
  • target discovery

Published Papers (2 papers)

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14 pages, 2675 KiB  
Article
Novel Anti-Melanoma Compounds Are Efficacious in A375 Cell Line Xenograft Melanoma Model in Nude Mice
by Sadeeshkumar Velayutham, Ryan Seerattan, Maab Sultan, Trisha Seal, Samaya Danthurthy, Baskaran Chinnappan, Jessica Landi, Kaitlyn Pearl, Aveta Singh, Keiran S. M. Smalley, Julia Zaias, Jun Yong Choi and Dmitriy Minond
Biomolecules 2023, 13(9), 1276; https://doi.org/10.3390/biom13091276 - 22 Aug 2023
Viewed by 1777
Abstract
Despite the successes of immunotherapy, melanoma remains one of the deadliest cancers, therefore, the need for innovation remains high. We previously reported anti-melanoma compounds that work by downregulating spliceosomal proteins hnRNPH1 and H2. In a separate study, we reported that these compounds were [...] Read more.
Despite the successes of immunotherapy, melanoma remains one of the deadliest cancers, therefore, the need for innovation remains high. We previously reported anti-melanoma compounds that work by downregulating spliceosomal proteins hnRNPH1 and H2. In a separate study, we reported that these compounds were non-toxic to Balb/C mice at 50 mg/kg suggesting their utility in in vivo studies. In the present study, we aimed to assess the efficacy of these compounds by testing them in A375 cell-line xenograft in nude athymic mice. Animals were randomized into four groups (n = 12/group): 10 mg/kg vemurafenib, and 25 mg/kg 2155-14 and 2155-18 thrice a week for 15 days along with a control group. The results revealed that both 2155-14 and 2155-18 significantly decreased the growth of A375 tumors, which was comparable to vemurafenib. These results were confirmed by tumor volume, weight, and histopathological examination. In conclusion, these results demonstrate the therapeutic potential of targeting spliceosomal proteins hnRNPH1 and H2. Full article
(This article belongs to the Special Issue Advances in Melanoma Targeted Therapy)
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9 pages, 1567 KiB  
Brief Report
In Vivo Acute Toxicity Studies of Novel Anti-Melanoma Compounds Downregulators of hnRNPH1/H2
by Sadeeshkumar Velayutham, Trisha Seal, Samaya Danthurthy, Julia Zaias, Keiran S. M. Smalley and Dmitriy Minond
Biomolecules 2023, 13(2), 349; https://doi.org/10.3390/biom13020349 - 10 Feb 2023
Cited by 1 | Viewed by 1894
Abstract
Despite the recent advances in melanoma therapy, the need for new targets and novel approaches to therapy is urgent. We previously reported melanoma actives that work via binding and downregulating spliceosomal proteins hnRNPH1 and H2. Given the lack of knowledge about the side [...] Read more.
Despite the recent advances in melanoma therapy, the need for new targets and novel approaches to therapy is urgent. We previously reported melanoma actives that work via binding and downregulating spliceosomal proteins hnRNPH1 and H2. Given the lack of knowledge about the side effects of using spliceosomal binders in humans, an acute toxicity study was conducted to evaluate these compounds in mice. Male and female mice were treated with compounds 2155-14 and 2155-18 at 50 mg/kg/day via subcutaneous injections, and the clinical signs of distress were monitored for 21 days and compared with control mice. Additionally, the effect of the leads on blood chemistry, blood cell counts, and organs was evaluated. No significant changes were observed in the body weight, blood cell count, blood chemistry, or organs of the mice following the compound treatment. The results show that our compounds, 2155-14 and 2155-18, are not toxic for the study period of three weeks. Full article
(This article belongs to the Special Issue Advances in Melanoma Targeted Therapy)
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