Genetics and Genomics of HPV and Cervical Cancer

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".

Deadline for manuscript submissions: closed (20 May 2024) | Viewed by 2958

Special Issue Editors


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Guest Editor
Department of Obstetrics and Gynaecology, University of Thessaly, Larissa, Greece
Interests: HPV; Cervical cancer; gynecological oncology; gynecological surgery

E-Mail Website
Guest Editor Assistant
Department of Obstetrics and Gynaecology, University of Thessaly, Larissa, Greece
Interests: Gynecological oncology; gynecological surgery; biomarkers in Obstetrics and Gynecology

Special Issue Information

Dear Colleagues,

Cervical cancer is the fourth most common cancer amongst female patients worldwide. Infection by high-risk human papilloma virus (HPV) is necessary in most cases, but not sufficient to develop invasive cervical cancer. DNA sequence differences between HPV genomes determine whether an HPV infection has the potential for carcinogenesis. Despite the high frequency of HPV infections, in most cases the virus is cleared by the host immune response and only a small proportion of infected individuals develop persistent infections that can result in malignant transformation, indicating that other biological, genetic and environmental factors may influence individual susceptibility to HPV-associated cancers. Genetic factors contributing to the development of cervical dysplasia and invasive cervical cancer are largely unknown. However, genetic variants that appear to be associated with genes that predispose or protect the host to HPV infections, thereby affecting individual susceptibility, have been reported. The hypothesis of germline predisposition suggested that heritability via genetic factors might contribute to cervical cancer risk variation.

Prof. Dr. Alexandros Daponte
Guest Editor

Athina A. Samara
Guest Editor Assistant

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Keywords

  • gene association studies
  • cervical cancer
  • gene association studies
  • head and neck squamous cell carcinomas
  • human papillomaviruses
  • virus-induced cancers
  • genome-wide association studies carcinomas
  • human papillomaviruses
  • virus-induced cancers
  • genome-wide association studies

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Published Papers (2 papers)

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Review

22 pages, 1524 KiB  
Review
Oncofertility and Fertility Preservation for Women with Gynecological Malignancies: Where Do We Stand Today?
by Valentina Di Nisio, Nikoletta Daponte, Christina Messini, George Anifandis and Sevastiani Antonouli
Biomolecules 2024, 14(8), 943; https://doi.org/10.3390/biom14080943 - 3 Aug 2024
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Abstract
Oncofertility is a growing medical and research field that includes two main areas: oncology and reproductive medicine. Nowadays, the percentage of patients surviving cancer has exponentially increased, leading to the need for intervention for fertility preservation in both men and women. Specifically, gynecological [...] Read more.
Oncofertility is a growing medical and research field that includes two main areas: oncology and reproductive medicine. Nowadays, the percentage of patients surviving cancer has exponentially increased, leading to the need for intervention for fertility preservation in both men and women. Specifically, gynecological malignancies in women pose an additional layer of complexity due to the reproductive organs being affected. In the present review, we report fertility preservation options with a cancer- and stage-specific focus. We explore the drawbacks and the necessity for planning fertility preservation applications during emergency statuses (i.e., the COVID-19 pandemic) and comment on the importance of repro-counseling for multifaceted patients during their oncological and reproductive journey. Full article
(This article belongs to the Special Issue Genetics and Genomics of HPV and Cervical Cancer)
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14 pages, 1137 KiB  
Review
Cervical Cancer Genetic Profile through Circulating Tumor DNA: What Can We Learn from Blood?
by Sevastiani Antonouli, Valentina Di Nisio, Nikoletta Daponte, Athina-Ioanna Daponte and Alexandros Daponte
Biomolecules 2024, 14(7), 825; https://doi.org/10.3390/biom14070825 - 10 Jul 2024
Viewed by 1303
Abstract
Cervical cancer (CC) is one of the deadliest gynecological cancers worldwide. Human papillomavirus is the main etiological agent responsible for the initiation and development of most CC cases. The standard method utilized for CC screening in the global population is the cytological Pap [...] Read more.
Cervical cancer (CC) is one of the deadliest gynecological cancers worldwide. Human papillomavirus is the main etiological agent responsible for the initiation and development of most CC cases. The standard method utilized for CC screening in the global population is the cytological Pap smear test. Despite its effective validity in detecting precancerous lesions and its response to layer stages of this disease, greater screening and diagnostic reliability are needed, as well as an improvement in specificity and sensitivity. In this context, the use of liquid biopsies, like blood, for the isolation of circulating tumor DNA (ctDNA) in CC screening, diagnosis, prognosis, and surveillance could fill the gaps that still exist. In the present review, we aim to study the literature in order to collect knowledge on blood-based liquid biopsy based on descriptions of its precious molecular content and its utilization as a potential tool for CC patients’ management. We will mainly focus on the important role of the novel ctDNA and the unique possibilities to additionally use HPV-ctDNA in CC at various stages of clinical application. Full article
(This article belongs to the Special Issue Genetics and Genomics of HPV and Cervical Cancer)
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