Protein Glycosylation and Human Diseases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Carbohydrates".
Deadline for manuscript submissions: closed (10 December 2023) | Viewed by 29729
Special Issue Editors
Interests: glycosylation; glycobiology; glycomics; immunity; immunoglobulin G; biomarker
Interests: glycomics, glycoproteomics; glycosylation
Interests: protein glycosylation; glycosylation; glycomics; glycan
Special Issue Information
Dear Colleagues,
Glycosylation is the most diverse posttranslational protein modification and is profoundly involved in a plethora of biological processes, including disease development and aggravation. Despite recent analytical developments, many aspects of the glycosylation process still remain unknown, both in health and disease. Contrary to genetic biomarkers, which are set for a lifetime, human glycome is dynamic and undergoes changes in response to physiological triggers, immune challenges and pathophysiological processes. Thus, most human diseases, including inflammatory, autoimmune, infectious and cardiometabolic diseases, and cancer, show associations with specific changes in glycan composition that often precede disease onset. As the structural diversity of glycome represents a complex pool of information, glycosylation changes can be specific for the disease and/or disease stage, which makes them valuable diagnostic and prognostic markers as well as a target for therapeutic interventions.
In this context, this Special Issue is collecting research articles and targeted reviews that address the most recent advances related to protein glycosylation in common complex diseases. Contributions that cover the development and improvements of analytical approaches for glycosylation analysis are very welcome, as well as research describing applications of state-of-the-art glycoprofiling methods and technologies in monitoring glycosylation pattern changes during disease development, progression and intervention (e.g., response to therapy, lifestyle changes). Finally, we welcome new insights that elucidate the structural and functional implications of glycoprotein heterogeneity in complex pathologies.
Prof. Dr. Gordan Lauc
Dr. Maja Pucic Bakovic
Dr. Ivan Gudelj
Dr. Tamara Štambuk
Guest Editors
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Keywords
- glyco(proteo)mics
- glycosylation in diseases (inflammatory, cardiovascular, metabolic)
- biomarker discovery
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