New Insights into DNA Polymerases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Synthetic Biology and Bioengineering".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 132
Special Issue Editor
Interests: DNA polymerases; DNA damage; mutagenesis; chemotherapy; cancer biology; synthetic biology; nucleoside analogs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
DNA polymerases are essential enzymes in biology as they participate in key aspects of nucleic acid metabolism including replication, repair, and recombination. There are two general classes of DNA polymerases. The first, denoted as high-fidelity, are typically involved in the faithful duplication of chromosomal and mitochondrial genomes. The second are denoted as “specialized” due to their unique ability to efficiently replicate various DNA lesions that escape DNA repair. The mechanisms regarding their activities both in vitro and in vivo have been extensively studied using various techniques including kinetic, structural, single-molecule, and mutagenesis approaches. This Special Issue focuses on how these remarkable enzymes are used in different applications in contemporary areas of biotechnology. Topics of interest to this Special Issue include historical perspectives and summaries of recent advancements in using both types of enzymes in the polymerase chain reaction (PCR) in diagnostic and molecular medicine as well as in forensic science. Another area discusses how DNA polymerases are applied in areas of synthetic biology to develop novel biopolymers with unique chemical properties. Finally, experts will describe efforts using DNA polymerases as efficient and dependable reagents in DNA digital data storage, an exciting technology that will revolutionize the interface between biology and electronics.
Prof. Dr. Anthony J. Berdis
Guest Editor
Manuscript Submission Information
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Keywords
- DNA polymerases
- polymerase chain reaction
- mutagenesis
- synthetic biology
- DNA digital storage
- high-fidelity polymerases
- specialized polymerases
