Notch Signalling and Cell Fate
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (1 October 2021) | Viewed by 22149
Special Issue Editor
Interests: Notch; Drosophila; endocytosis; signalling; ubiquitin ligases; structure/function
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Notch is an evolutionarily conserved cell membrane receptor that mediates a vital developmental signalling pathway. Notch activation results from its proteolytic cleavage and release of its intracellular domain. The latter translocates to the nucleus and itself becomes part of the transcription factor complex that then activates Notch target genes. Despite the apparent simplicity of the pathway, with its limited number of core components, there is a huge variety of cell fate outcomes regulated by Notch, affecting cell differentiation, proliferation and apoptosis, across a plethora of developmental contexts. These include a variety of patterning processes, such lateral inhibition, boundary formation, and binary cell fate decisions across many different tissues. Notch continues to be of vital importance in the adult organism for regulation of tissue renewal, homeostasis and repair. Understanding how this complexity arises is of considerable interest and importance because altered Notch activity is associated with an increasing number of pathological conditions, including developmental disorders and cancer. Recent work has highlighted how complexity of outcomes can arise from modulations of the duration and amplitude of the Notch signal, and by the integration and convergence of signals that impinge on the control regions of target genes. The regulatory networks that integrate different inputs and modulate the dynamics of the signal therefore have an important role to play in directing proper cell fate decisions across space and time. This Special Issue aims to shed light on the Notch regulatory mechanisms that control such cell fate decisions. Areas of interest include, but are not limited to, the specialisation of different Notch homologues, regulation of Notch signalling dynamics, analysis of Notch regulatory networks and cross talk, Notch and stem cells, Notch-regulated cell fate decisions in disease, roles of chromatin modifications, and the contributions of mathematical modelling to the study of Notch regulatory networks.
We look forward to receiving and reading your contributions in the form of either original research or topical reviews.
Dr. Martin Baron
Guest Editor
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Keywords
- Notch
- cell fate
- developmental pattering
- stem cells
- computational modelling
- signal dynamics
- signalling networks and cross talk
- Notch and disease
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