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Biosensors
Special Issues
Intracellular Optical Bio-sensing in Biomedicine
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Intracellular Optical Bio-sensing in Biomedicine

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3425

Special Issue Editor

Dr. Barbara Adinolfi

E-Mail Website
Guest Editor
Institute of Applied Physics "Nello Carrara", Consiglio Nazionale delle Ricerche (CNR), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy
Interests: optical bio-sensing; fluorescence; confocal microscopy; theranostics; cell imaging; cancer; intracellular biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The purpose of this Special Issue is to gather researchers active in the development of intracellular optical bio-sensing based approaches applied to biomedicine. Biomedicine aims to study organ physiology and pathology, biomedical technologies, and many other therapeutic applications. This includes rational, innovative, and diagnostic/therapeutic approaches deriving from the understanding of the molecular mechanisms of cellular functions. For these reasons, I encourage researchers to describe innovative approaches based on intracellular optical bio-sensing that can potentially be used for early diagnosis, to follow the evolution of the disease in real time and/or as therapeutic agents.

I cordially invite you to share your work, expertise, and insights with the scientific community in the form of research articles and reviews for this Special Issue.

Dr. Barbara Adinolfi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Intracellular Optical Bio-sensing
  • Theranostics
  • Molecular beacons
  • Biomedicine
  • Intracellular targets
  • Diagnosis
  • Therapy
  • Mechanism of action

Published Papers (1 paper)

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Research

10 pages, 4271 KiB  
Communication
Fluorescent Carbon Dots for Sensitive and Rapid Monitoring of Intracellular Ferrous Ion
by Le Minh Tu Phan, Thi Xoan Hoang and Sungbo Cho
Biosensors 2022, 12(1), 41; https://doi.org/10.3390/bios12010041 - 14 Jan 2022
Cited by 11 | Viewed by 2994
Abstract
Although iron is an essential constituent for almost all living organisms, iron dyshomeostasis at a cellular level may trigger oxidative stress and neuronal damage. Hence, there are numerous reported carbon dots (CDs) that have been synthesized and applied to determine intracellular iron ions. [...] Read more.
Although iron is an essential constituent for almost all living organisms, iron dyshomeostasis at a cellular level may trigger oxidative stress and neuronal damage. Hence, there are numerous reported carbon dots (CDs) that have been synthesized and applied to determine intracellular iron ions. However, among reported CDs focused to detect Fe3+ ions, only a few CDs have been designed to specifically determine Fe2+ ions over Fe3+ ions for monitoring of intracellular Fe2+ ions. We have developed the nitrogen-doped CDs (NCDs) for fluorescence turn-off detection of Fe2+ at cellular level. The as-synthesized NCDs exhibit a strong blue fluorescence and low cytotoxicity, acting as fluorescence probes to detect Fe2+ as low as 0.702 µM in aqueous solution within 2 min and visualize intracellular Fe2+ in the concentration range from 0 to 500 µM within 20 min. The as-prepared NCDs possess some advantages such as high biocompatibility, strong fluorescence properties, selectivity, and rapidity for intracellular Fe2+ monitoring, making NCDs an excellent nanoprobe for biosensing of intracellular ferrous ions. Full article
(This article belongs to the Special Issue Intracellular Optical Bio-sensing in Biomedicine)
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