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Biosensors
Special Issues
Flexible Optical and Electrical Biosensors
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Flexible Optical and Electrical Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (15 March 2022) | Viewed by 6705

Special Issue Editors

Dr. Xin Shan

E-Mail Website
Guest Editor
Department of Industrial and Manufacturing Engineering, High-Performance Materials Institute, FAMU-FSU College of Engineering, Florida State University, Tallahassee, FL 32310, USA
Interests: flexible and stretchable opto-electronics; polymer composites
Prof. Dr. Cosimino Malitesta

E-Mail Website
Guest Editor
Laboratorio di Chimica Analitica, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali (DiSTeBA), Università del Salento, Via Per Monteroni, 73100 Lecce, Italy
Interests: electrochemical biosensors and biomimetic sensors; electrosynthesised polymers and conducting polymers; electrochemical techniques in molecular imprinting polymerisation; chemical and chemometric techniques for enhancing XPS quantitation capability; analytical applications of metallic and oxide nanoparticles

Special Issue Information

Dear Colleagues,

There’s increasing demand for deformable optical and electrical devices in the healthcare industry. Flexible light-emitting diodes and photodetectors can be used for pulse oximetry that monitors the blood oxygen, especially in the time of the global COVID-19 pandemic. The deformable pressure sensor arrays can be used for helmet comfort monitoring and head protection, which can be widely used in infrastructure, manufacturing, and athletic healthcare. In addition, light-emitting diodes and lasers can be used for certain light therapy that saves thousands of lives and helps to improve the quality of people’s daily life.

From the standpoint of materials, carbon-based nanomaterials, such as carbon nanotubes (CNTs) and graphene, are widely used materials in flexible pressure sensors. Other metal-nanoparticle-filled composites are frequently seen in the reports. Semiconductors are also a large portion of flexible and stretchable sensors. Organic semiconductors and solution-processed halide perovskites bring new possibilities to deformable optoelectronics. Perovskites have attracted numerous studies due to their exceptional optical and electrical properties since 2009. Flexible and stretchable light-emitting diodes and photodetectors based on perovskites and polymer composites have also been reported since 2015. There are other types of materials that can be used in deformable optical and electrical devices, such as metal–organic frameworks (MOFs). It is believed that there will be more and more reports of novel materials that can be used in deformable devices that benefit human health and development.

Dr. Xin Shan
Prof. Dr. Cosimino Malitesta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Polymer
  • Photodetector
  • Light-emitting diode
  • Flexible
  • Stretchable

Published Papers (2 papers)

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Research

12 pages, 2522 KiB  
Article
Differential Amperometric Microneedle Biosensor for Wearable Levodopa Monitoring of Parkinson’s Disease
by Lu Fang, Hangxu Ren, Xiyu Mao, Shanshan Zhang, Yu Cai, Shiyi Xu, Yi Zhang, Lihua Li, Xuesong Ye and Bo Liang
Biosensors 2022, 12(2), 102; https://doi.org/10.3390/bios12020102 - 7 Feb 2022
Cited by 9 | Viewed by 3716
Abstract
Levodopa (L-Dopa) is considered to be one of the most effective therapies available for Parkinson’s disease (PD) treatment. The therapeutic window of L-Dopa is narrow due to its short half-life, and long-time L-Dopa treatment will cause some side effects such as dyskinesias, psychosis, [...] Read more.
Levodopa (L-Dopa) is considered to be one of the most effective therapies available for Parkinson’s disease (PD) treatment. The therapeutic window of L-Dopa is narrow due to its short half-life, and long-time L-Dopa treatment will cause some side effects such as dyskinesias, psychosis, and orthostatic hypotension. Therefore, it is of great significance to monitor the dynamic concentration of L-Dopa for PD patients with wearable biosensors to reduce the risk of complications. However, the high concentration of interferents in the body brings great challenges to the in vivo monitoring of L-Dopa. To address this issue, we proposed a minimal-invasive L-Dopa biosensor based on a flexible differential microneedle array (FDMA). One working electrode responded to L-Dopa and interfering substances, while the other working electrode only responded to electroactive interferences. The differential current response of these two electrodes was related to the concentration of L-Dopa by eliminating the common mode interference. The differential structure provided the sensor with excellent anti-interference performance and improved the sensor’s accuracy. This novel flexible microneedle sensor exhibited favorable analytical performance of a wide linear dynamic range (0–20 μM), high sensitivity (12.618 nA μM−1 cm−2) as well as long-term stability (two weeks). Ultimately, the L-Dopa sensor displayed a fast response to in vivo L-Dopa dynamically with considerable anti-interference ability. All these attractive performances indicated the feasibility of this FDMA for minimal invasive and continuous monitoring of L-Dopa dynamic concentration for Parkinson’s disease. Full article
(This article belongs to the Special Issue Flexible Optical and Electrical Biosensors)
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13 pages, 1655 KiB  
Article
Computational Design of a Molecularly Imprinted Polymer for the Biomonitoring of the Organophosphorous Metabolite Chlorferron
by Bakhtiyar Qader, Issam Hussain, Mark Baron, Rebeca Jiménez-Pérez, Guzmán Gil-Ramírez and Jose Gonzalez-Rodriguez
Biosensors 2021, 11(6), 192; https://doi.org/10.3390/bios11060192 - 10 Jun 2021
Cited by 5 | Viewed by 2255
Abstract
Coumaphos is an organophosphorus compound used as insecticide and frequently used by beekeepers for the management of parasitic mites. The most important metabolite, chlorferron (CFN), has been identified in biological samples and foodstuff. The need to quickly identify the presence of typical metabolites, [...] Read more.
Coumaphos is an organophosphorus compound used as insecticide and frequently used by beekeepers for the management of parasitic mites. The most important metabolite, chlorferron (CFN), has been identified in biological samples and foodstuff. The need to quickly identify the presence of typical metabolites, as an indication of interaction with coumaphos has driven the need to produce a highly sensitive electrochemical method for chlorferron analysis, based on molecularly imprinting polymers (MIP) technology. It showed irreversible behaviour with mixed diffusion/adsorption-controlled reactions at the electrode surface. A monoelectronic mechanism of reaction for oxidation has also been suggested. The linear range observed was from 0.158 to 75 µM. Median precision in terms of %RSD around 3% was also observed. For DPV, the limit of detection (LOD) and the limit of quantitation (LOQ) for the CFN-MIP were 0.158 µM and 0.48 µM, respectively. The obtained median % recovery was around 98%. The results were also validated to reference values obtained using GC-MS. Urine and human synthetic plasma spiked with CFN were used to demonstrate the usability of the method in biological samples, showing the potential for biomonitoring. The developed imprinted sensor showed maximum signal change less than 16.8% when related metabolites or pesticide were added to the mix, suggesting high selectivity of the MIP sensor toward CFN molecules. The results from in vitro metabolism of CMP analysed also demonstrates the potential for detection and quantification of CFN in environmental samples. The newly developed CFN-MIP sensor offers similar LoDs than chromatographic methods with shorter analysis time. Full article
(This article belongs to the Special Issue Flexible Optical and Electrical Biosensors)
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