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Cancers
Special Issues
Advances in Oral Cancers and Precancers
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Advances in Oral Cancers and Precancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: 10 December 2024 | Viewed by 4187

Special Issue Editors

Dr. Daniela Adamo

E-Mail Website
Guest Editor
Department of Neurosciences, Reproductive Science and Dentistry, Oral Medicine Unit, Federico II University of Naples, Via Pansini 5, 80138 Naples, Italy
Interests: oral cancer; oral potentially malignant disorders; erytroplakia; leukoplakia; oral lichen planus; autoimmune mucocutaneous bullous diseases; burning mouth syndrome
Prof. Dr. Michele Davide Mignogna

E-Mail Website
Guest Editor
Department of Neurosciences, Reproductive Science and Dentistry, Oral Medicine Unit, Federico II University of Naples, Via Pansini 5, 80138 Naples, Italy
Interests: oral cancer; oral potentially malignant disorders; erytroplakia; leukoplakia; oral lichen planus; autoimmune mucocutaneous bullous diseases; burning mouth syndrome
Dr. Stefania Leuci

E-Mail Website
Guest Editor
Department of Neurosciences, Reproductive Science and Dentistry, Oral Medicine Unit, Federico II University of Naples, Via Pansini 5, 80138 Naples, Italy
Interests: oral cancer; oral potentially malignant disorders; erytroplakia; leukoplakia; oral lichen planus; autoimmune mucocutaneous bullous diseases; burning mouth syndrome
Special Issues, Collections and Topics in MDPI journals
Dr. Noemi Coppola

E-Mail Website
Guest Editor
Department of Neurosciences, Reproductive Science and Dentistry, Oral Medicine Unit, Federico II University of Naples, Via Pansini 5, 80138 Naples, Italy
Interests: oral cancer; oral potentially malignant disorders; erythroplakia; leukoplakia; oral lichen planus; autoimmune mucocutaneous bullous diseases; burning mouth syndrome
Dr. Elena Calabria

E-Mail Website
Guest Editor
Department of Neurosciences, Reproductive Science and Dentistry, Oral Medicine Unit, Federico II University of Naples, Via Pansini 5, 80138 Naples, Italy
Interests: oral pathology; oral medicine; oral cancer; burning mouth syndrome; oral potentially malignant disorders; pemphigus vulgaris; oral mucous membrane pemphigoid

Special Issue Information

Dear Colleagues,

Oral cancer is a large global health problem representing the major cause of death from oral diseases worldwide. Several OSCC risk factors have been identified, the main ones being tobacco and alcohol, which seem to have a synergistic effect, and oral HPV infection. Despite the improvements in medical and surgical techniques, the prognostic data have not changed significantly over the last 10 years, and the total five-year survival rate is around 50%. Oral cancers are often preceded by oral potentially malignant disorders (OPMDs), usually associated with genetic alterations that may lead to dysplastic transformation. The disorders listed as OPMDs, e.g., leukoplakia, erythroplakia, oral lichen planus, actinic cheilitis, and oral lichenoid lesion, have a wide range of clinical features with variable morphology. The potential of OPMDs for cancer progression varies according to a range of patient- or lesion-related factors, such as clinical appearance, size and site of lesion, sex and habits. There are no strategies to avoid the risk of malignant transformation. To date, the early detection of OPMDs remains the most effective strategy to reduce the incidence of oral cancer. We are pleased to invite you to contribute to this Special Issue with research papers in the field of OPMDs and oral cancer. This Special Issue aims to analyze all factors that could minimize oral cancer risk, improve prevention and control measures with the early detection of OPMDs, and apply detection procedures so that oro-pharyngeal cancers can be recognized at an early stage.

In this Special Issue, original research articles and reviews are welcome. Research areas may include, but are not limited to, the following:

  • Oral cancer;
  • Oral potentially malignant disorders;
  • Oral cancer prognosis;
  • Field cancerization;
  • Novel insights in OPMDs.

We look forward to receiving your contributions.

Dr. Daniela Adamo
Prof. Dr. Michele Davide Mignogna
Dr. Stefania Leuci
Dr. Noemi Coppola
Dr. Elena Calabria
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral cancer
  • oral squamous cell carcinoma
  • OPMD
  • leukoplakia
  • erythroplakia
  • smoking
  • human papilloma virus
  • field cancerization
 

Published Papers (2 papers)

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Research

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16 pages, 279 KiB  
Article
Oral Problems in Oncology Patients Undergoing Chemotherapy for Solid Tumors: A Prospective Observational Study
by Giulia Ottaviani, Giada Targato, Katia Rupel, Margherita Gobbo, Daniele Generali, Alessandra Guglielmi, Angela Dicorato, Daniela Adamo, Federica Canfora, Roberto Di Lenarda and Matteo Biasotto
Cancers 2024, 16(1), 176; https://doi.org/10.3390/cancers16010176 - 29 Dec 2023
Viewed by 739
Abstract
PURPOSE: Oral problems in a group of oncological patients undergoing chemotherapy (CT) for solid tumors have been examined. Incidence and severity of patients’ self-reported oral problems have been evaluated along their interaction with age, gender, tumor diagnosis and stage, presence of mestastasis, CT [...] Read more.
PURPOSE: Oral problems in a group of oncological patients undergoing chemotherapy (CT) for solid tumors have been examined. Incidence and severity of patients’ self-reported oral problems have been evaluated along their interaction with age, gender, tumor diagnosis and stage, presence of mestastasis, CT agent type, and number of CT cycle. We also analyzed the presence of paraesthesia and anaesthesia and their predisposing factors associated with clinical and treatment-related variables. METHODS: Patients were asked to fill in a questionnaire to evaluate the onset and the intensity of oral and perioral pain, oral mucositis, salivary gland hypofunction, dysgeusia, dysphagia, dysphonia, and sensitivity neuropathy (paraesthesia or dysaesthesia) since the last CT infusion. We also investigated which types of medications have possibly been used and who recommended it, as well as patients’ degree of awareness about the possibility of oral problems arising during CT. RESULTS: We recruited 194 patients and obtained 491 questionnaires. We found that a metastatic disease was a risk factor for OM (OR 2.02, p = 0.026) and salivary gland hypofunction (OR 1.66, p = 0.042) and that platinum agents, compared to mitotic inhibitors, increased the risk of developing salivary gland hypofunction (OR 2.16, p = 0.013), dysphagia (OR 3.26, p = 0.001), and anaesthesia (OR 5.16, p = 0.041). Young age was a slight protective factor for most symptoms. The 80% of enrolled patients were informed by the oncologist about possible oral problems arising during CT. CONCLUSIONS: Our study highlighted the importance of collecting observational data from the patients’ perspective on oral problems arising during the routine oncology practice, across a range of solid tumors and CT regimens. The relevance of these findings focused on the key role of the multidisciplinary team in advising the patients on the possible occurrence of oral problems, also by recommending their management. Full article
(This article belongs to the Special Issue Advances in Oral Cancers and Precancers)

Other

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25 pages, 1320 KiB  
Systematic Review
Role of Hemidesmosomes in Oral Carcinogenesis: A Systematic Review
by Jordan Nguyen, Tze Wei Chong, Hafsa Elmi, Jiani Ma, John Madi, Asha Mamgain, Eileen Melendez, Julian Messina, Nikhil Mongia, Sanjana Nambiar, Tsu Jie Ng, Huy Nguyen, Michael McCullough, Federica Canfora, Lorraine A. O’Reilly, Nicola Cirillo, Rita Paolini and Antonio Celentano
Cancers 2023, 15(9), 2533; https://doi.org/10.3390/cancers15092533 - 28 Apr 2023
Viewed by 2797
Abstract
Background: Oral cancers have limited diagnostic tools to aid clinical management. Current evidence indicates that alterations in hemidesmosomes, the adhesion complexes primarily involved in epithelial attachment to the basement membrane, are correlated to cancer phenotype for multiple cancers. This systematic review aimed to [...] Read more.
Background: Oral cancers have limited diagnostic tools to aid clinical management. Current evidence indicates that alterations in hemidesmosomes, the adhesion complexes primarily involved in epithelial attachment to the basement membrane, are correlated to cancer phenotype for multiple cancers. This systematic review aimed to assess the experimental evidence for hemidesmosomal alterations, specifically in relation to oral potentially malignant disorders and oral squamous cell carcinomas. Methods: We conducted a systemic review to summarise the available literature on hemidesmosomal components and their role in oral pre-cancer and cancer. Relevant studies were retrieved from a comprehensive search of Scopus, Ovid MEDLINE, Ovid Embase and Web of Science. Results: 26 articles met the inclusion criteria, of which 19 were in vitro studies, 4 in vivo studies, 1 in vitro and in vivo study, and 2 in vitro and cohort studies. Among them, 15 studies discussed individual alpha-6 and/or beta-4 subunits, 12 studies discussed the alpha-6 beta-4 heterodimers, 6 studies discussed the entire hemidesmosome complex, 5 studies discussed bullous pemphigoid-180, 3 studies discussed plectin, 3 studies discussed bullous pemphigoid antigen-1 and 1 study discussed tetraspanin. Conclusion: Heterogeneity in cell type, experimental models, and methods were observed. Alterations in hemidesmosomal components were shown to contribute to oral pre-cancer and cancer. We conclude that there is sufficient evidence for hemidesmosomes and their components to be potential biomarkers for evaluating oral carcinogenesis. Full article
(This article belongs to the Special Issue Advances in Oral Cancers and Precancers)
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