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Cancers
Special Issues
Cervical Cancer: Clinical Feature, Trial and Management
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Cervical Cancer: Clinical Feature, Trial and Management

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 907

Special Issue Editors

Prof. Dr. Roberto Tozzi

E-Mail Website
Guest Editor
Division of Women and Children’s Health, Department of Gynaecology and Obstetrics, University of Padua, 35122 Padua, Italy
Interests: gynecologic
Dr. Marco Noventa

E-Mail Website
Guest Editor
Unit of Gynecology and Obstetrics, Department of Women’s and Children’s Health, Unversity of Padova, 35122 Padua, Italy
Interests: sugery; laparoscopy; hysteroscopy; ultrasound; gynecological malignancies; diagnosis
Dr. Carlo Saccardi

E-Mail Website
Guest Editor
Department of Women’s and Children’s Health, Università degli Studi di Padova, Padua, Italy
Interests: gynaecology; obstetrics

Special Issue Information

Dear Colleagues,

Cervical cancer (CC) is a major public health problem, ranking as the fourth most common cause of cancer incidence and mortality in women worldwide. 

The staging and management of cervical cancer have been recently updated by several international societies, namely the FIGO, ASGO, SGO, and ESGO/ESTRO/ESP. The latter produced a fairly robust document entitled “Guidelines for the management of patients with cervical cancer - Update 2023”. However, there are still many areas open for debate or re-thinking, and there are still many novelties in treatment that require further investigation. As examples, we can cite the role of minimally invasive surgery (laparoscopy–robotic), the treatment of bulky or locally advanced CC, the role of sentinel-node evaluation via ultra-staging, the role of chemo-radiation, the safety and efficacy of adjuvant chemotherapy after definitive CTRT, and the role of immunotherapy.

We are pleased to invite you to publish your research in our Special Issue which will cover all debated topics relating to the diagnosis and treatment of patients with CC, including surgical and medical therapy and the combination of both.

For this Special Issue, original research articles, systematic reviews, and meta-analyses are welcome.

Prof. Dr. Roberto Tozzi
Dr. Marco Noventa
Dr. Carlo Saccardi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cervical cancer
  • diagnosis
  • minimally invasive surgery
  • laparoscopy
  • locally advanced disease
  • management
  • treatment
  • adjuvant chemotherapy
  • immunotherapy

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Published Papers (1 paper)

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Research

13 pages, 973 KiB  
Article
Nerve-Sparing Laparoscopic Radical Hysterectomy (nsLRH) without Adjuvant Therapy in FIGO Stage IB3 Cervical Cancer Patients: Surgical Technique and Survival Outcomes
by Roberto Tozzi, Sofia Bigardi, Giulia Spagnol, Federico Ferrari, Carlo Saccardi, Marco Noventa and Matteo Marchetti
Cancers 2024, 16(19), 3355; https://doi.org/10.3390/cancers16193355 - 30 Sep 2024
Viewed by 624
Abstract
(1) Background: In 2018 FIGO reclassified tumors confined to the cervix larger than 4 cm as stage IB3. Although concurrent CTRT has been the standard of care and surgery the alternative, optimal management remains controversial due to the lack of direct comparison between [...] Read more.
(1) Background: In 2018 FIGO reclassified tumors confined to the cervix larger than 4 cm as stage IB3. Although concurrent CTRT has been the standard of care and surgery the alternative, optimal management remains controversial due to the lack of direct comparison between surgery and CTRT. (2) Methods: This prospective observational study investigated the efficacy, safety and oncologic outcomes of nerve-sparing laparoscopic radical hysterectomy (nsLRH) for FIGO stage IB3 cervical cancer patients (IB3). From 2009 to 2023, IB3 patients underwent laparoscopic pelvic lymphadenectomies with frozen section analysis, followed by a nsLRH if the lymph nodes were tumor-free. No uterine manipulator was used and the vaginal cuff was sealed before retrieving the specimen. Intermediate-risk patients were under close observation without adjuvant therapy. Outcomes were monitored until 2023. (3) Results: During the study period, 74 IB3 patients were treated. Sixty-eight (91.9%) underwent a nsLRH. A complete resection with negative margins was achieved in all cases. At a median of 68 months of follow-up, the disease-free survival (DFS) rate was 89.7% and the overall survival (OS) rate was 93.1%. The overall complication rate was 23.5% and there were no grade 4–5 complications. (4) Conclusions: In patients with IB3 cervical cancer, a nsLRH is safe and effective. While awaiting the results from ongoing randomized trials, these findings support nsLRH as a viable treatment. Full article
(This article belongs to the Special Issue Cervical Cancer: Clinical Feature, Trial and Management)
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