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Cancers
Special Issues
The Cancer Microenvironment and Its Impact on Cell Adhesion, Migration...
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The Cancer Microenvironment and Its Impact on Cell Adhesion, Migration and Invasion

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1190

Special Issue Editor

Dr. Tracey Martin

E-Mail Website
Guest Editor
School of Medicine, Cardiff University, Cardiff CF10 3AT, UK
Interests: cancer metastasis; tight junctions; cell adhesion; molecular targets; blood–brain barrier; angiogenesis; endothelial cells; breast cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The cancer microenvironment is a system of extreme complexity. Cancer cells, fibroblasts, epithelial and endothelial cells, immune cells and fibroblasts all play a part in the composition of the local milieu. Growth factors, cytokines, extracellular matrix components and signalling events all contribute to the development and progression of tumours. Events such as cell detachment, adhesion, proliferation, migration, invasion and dysregulation are all played out within this environment. Advances in understanding the interplay involved are key to diagnosing and treating cancer. This Special Issue aims to highlight recent advances in the understanding of cell adhesion, migration and invasion within the tumour microenvironment.

Dr. Tracey Martin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • migration
  • invasion
  • cell adhesion
  • angiogenesis
  • microenvironment
  • junctional complexes
  • mechanisms

Published Papers (1 paper)

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Review

28 pages, 1588 KiB  
Review
Cellular Impacts of Striatins and the STRIPAK Complex and Their Roles in the Development and Metastasis in Clinical Cancers (Review)
by Amber Xinyu Li, Tracey A. Martin, Jane Lane and Wen G. Jiang
Cancers 2024, 16(1), 76; https://doi.org/10.3390/cancers16010076 - 22 Dec 2023
Cited by 1 | Viewed by 996
Abstract
Striatins (STRNs) are generally considered to be cytoplasmic proteins, with lower expression observed in the nucleus and at cell–cell contact regions. Together with protein phosphatase 2A (PP2A), STRNs form the core region of striatin-interacting phosphatase and kinase (STRIPAK) complexes through the coiled-coil region [...] Read more.
Striatins (STRNs) are generally considered to be cytoplasmic proteins, with lower expression observed in the nucleus and at cell–cell contact regions. Together with protein phosphatase 2A (PP2A), STRNs form the core region of striatin-interacting phosphatase and kinase (STRIPAK) complexes through the coiled-coil region of STRN proteins, which is crucial for substrate recruitment. Over the past two decades, there has been an increasing amount of research into the biological and cellular functions of STRIPAK members. STRNs and the constituent members of the STRIPAK complex have been found to regulate several cellular functions, such as cell cycle control, cell growth, and motility. Dysregulation of these cellular events is associated with cancer development. Importantly, their roles in cancer cells and clinical cancers are becoming recognised, with several STRIPAK components found to have elevated expression in cancerous tissues compared to healthy tissues. These molecules exhibit significant diagnostic and prognostic value across different cancer types and in metastatic progression. The present review comprehensively summarises and discusses the current knowledge of STRNs and core STRIPAK members, in cancer malignancy, from both cellular and clinical perspectives. Full article
(This article belongs to the Special Issue The Cancer Microenvironment and Its Impact on Cell Adhesion, Migration and Invasion)
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