New Insights into Kidney Disease Development and Therapy Strategies

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1251

Special Issue Editors

Special Issue Information

Dear Colleagues,

Basic science and practical issues related to etiological factors, methodology of analysis, diagnostic criteria, and therapeutic advances of neoplastic and non-neoplastic renal diseases are welcomed in this Special Issue, from renal epithelial/non-epithelial tumors to hereditary diseases, transplantation-related disorders, and glomerulonephritis. The Issue intends to bring together the experience of very different fields and serve as a unified forum for basic researchers, urologists, nephrologists, oncologists, pathologists, radiologists, and other related specialties.

You may choose our Joint Special Issue in Biomolecules.

Dr. José I. López
Dr. Claudia Manini
Guest Editors

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Published Papers (1 paper)

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Research

13 pages, 18480 KiB  
Article
Predicting Survival of Metastatic Clear Cell Renal Cell Cancer Treated with VEGFR-TKI-Based Sequential Therapy
by Javier C. Angulo, Gorka Larrinaga, David Lecumberri, Ane Miren Iturregui, Jon Danel Solano-Iturri, Charles H. Lawrie, María Armesto, Juan F. Dorado, Caroline E. Nunes-Xavier, Rafael Pulido, Claudia Manini and José I. López
Cancers 2024, 16(16), 2786; https://doi.org/10.3390/cancers16162786 - 7 Aug 2024
Viewed by 739
Abstract
(1) Objective: To develop a clinically useful nomogram that may provide a more individualized and accurate estimation of cancer-specific survival (CSS) for patients with clear-cell (CC) metastatic renal cell carcinoma (mRCC) treated with nephrectomy and vascular endothelial growth factor receptor–tyrosine kinase inhibitor (VEGFR-TKI)-based [...] Read more.
(1) Objective: To develop a clinically useful nomogram that may provide a more individualized and accurate estimation of cancer-specific survival (CSS) for patients with clear-cell (CC) metastatic renal cell carcinoma (mRCC) treated with nephrectomy and vascular endothelial growth factor receptor–tyrosine kinase inhibitor (VEGFR-TKI)-based sequential therapy. (2) Methods: A prospectively maintained database of 145 patients with mRCC treated between 2008 and 2018 was analyzed to predict the CSS of patients receiving sunitinib and second- and third-line therapies according to current standards of practice. A nomogram based on four independent clinical predictors (Eastern Cooperative Oncology Group status, International Metastatic RCC Database Consortium score, the Morphology, Attenuation, Size and Structure criteria and Response Evaluation Criteria in Solid Tumors response criteria) was calculated. The corresponding 1- to 10-year CSS probabilities were then determined from the nomogram. (3) Results: The median age was 60 years (95% CI 57.9–61.4). The disease was metastatic at diagnosis in 59 (40.7%), and 86 (59.3%) developed metastasis during follow-up. Patients were followed for a median 48 (IQR 72; 95% CI 56–75.7) months after first-line VEGFR-TKI initiation. The concordance probability estimator value for the nomogram is 0.778 ± 0.02 (mean ± SE). (4) Conclusions: A nomogram to predict CSS in patients with CC mRCC that incorporates patient status, clinical risk classification and response criteria to first-line VEGFR-TKI at 3 months is presented. This new tool may be useful to clinicians assessing the risk and prognosis of patients with mRCC. Full article
(This article belongs to the Special Issue New Insights into Kidney Disease Development and Therapy Strategies)
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