Advancements in Image-Guided Radiotherapy for the Treatment of Lung Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1764

Special Issue Editors


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Guest Editor
Radiation Oncology Department, University Hospital, 29200 Brest, France
Interests: lung cancer; functional imaging; stereotactic body radiotherapy; radiomics; quality of life; biomarkers

E-Mail Website
Guest Editor
Radiation Oncology Department, CHU de Brest, Brest, France
Interests: lung cancer; functional imaging; stereotactic body radiotherapy; radiomics; quality of life; biomarkers

Special Issue Information

Dear Colleagues,

Image-guided radiotherapy (IGRT) takes place at every step of the treatment in lung cancer, from treatment planning with fusion imaging, to daily in-room repositioning. Managing tumor and organ motion has been possible since the introduction of routine four-dimensional computed tomography (4DCT) use. The assessment of respiratory motion has been performed with “passive” techniques based on reconstruction images from 4DCT planning, or “active” techniques adapted to the patient's breathing. Additionally metabolic imaging has a great importance in radiotherapy planning, dose delivering and adaptive approach, with the aim to increase the accuracy in target definition and sparing of healthy tissues. Magnetic resonance imaging (MRI) and functional imaging also play an important role in lung cancer radiation and open the way for adaptive RT. Topics for this Special Issue include technical advances in RT and their clinical impact on lung cancer treatment.

Dr. François Lucia
Dr. Vincent Bourbonne
Guest Editors

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Keywords

  • lung cancer
  • functional imaging
  • stereotactic body radiotherapy
  • radiomics
  • biomarkers
  • artificial intelligence
  • magnetic resonance imaging

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Published Papers (1 paper)

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Research

11 pages, 2402 KiB  
Article
Optimizing Choice of Skin Surrogates for Surface-Guided Stereotactic Body Radiotherapy of Lung Lesions Using Four-Dimensional Computed Tomography
by Vanda Leipold, Ivana Alerić, Mihaela Mlinarić, Domagoj Kosmina, Fran Stanić, Mladen Kasabašić, Damir Štimac, Hrvoje Kaučić, Giovanni Ursi, Karla Schwarz, Igor Nikolić, Denis Klapan and Dragan Schwarz
Cancers 2024, 16(13), 2358; https://doi.org/10.3390/cancers16132358 - 27 Jun 2024
Viewed by 1539
Abstract
Image-guided radiotherapy supported by surface guidance can help to track lower lung lesions’ respiratory motion while reducing a patient’s exposure to ionizing radiation. However, it is not always clear how the skin’s respiratory motion magnitude and its correlation with the lung lesion’s respiratory [...] Read more.
Image-guided radiotherapy supported by surface guidance can help to track lower lung lesions’ respiratory motion while reducing a patient’s exposure to ionizing radiation. However, it is not always clear how the skin’s respiratory motion magnitude and its correlation with the lung lesion’s respiratory motion vary between different skin regions of interest (ROI). Four-dimensional computed tomography (4DCT) images provide information on both the skin and lung respiratory motion and are routinely acquired for the purpose of treatment planning in our institution. An analysis of 4DCT images for 57 patients treated in our institution has been conducted to provide information on the respiratory motion magnitudes of nine skin ROIs of the torso, a tracking structure (TS) representing a lower lung lobe lesion, as well as the respiratory motion correlations between the nine ROIs and the TS. The effects of gender and the adipose tissue volume and distribution on these correlations and magnitudes have been analyzed. Significant differences between the ROIs in both the respiratory motion magnitudes and their correlations with the TS have been detected. An overall negative correlation between the ROI respiratory magnitudes and the adipose tissue has been detected for ROIs with rib cage support. A weak to moderate negative correlation between the adipose tissue volume and ROI-to-TS respiratory correlations has been detected for upper thorax ROIs. The respiratory magnitudes in regions without rib support tend to be larger for men than for women, but no differences in the ROI-to-TS correlation between sexes have been detected. The described findings should be considered when choosing skin surrogates for lower lung lesion motion management. Full article
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