Lung Cancer Proteogenomics: New Era, New Insights

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: 15 January 2025 | Viewed by 1867

Special Issue Editor


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Guest Editor
Division of Biotechnology, Center of Systems Biology, Biomedical Research Foundation of the Academy of Athens (BRFAA), 11525 Athens, Greece
Interests: pediatric brain malignancies; proteins; omics

Special Issue Information

Dear Colleagues,

Lung cancer remains a major public health concern, constituting the second most prevalent malignancy and the leading cause of cancer-related mortality worldwide. Lung cancer incidence and outcomes vary depending on factors such as age, sex, ethnicity, smoking habits, environment, and socioeconomic status. Despite efforts to elucidate its molecular characteristics, it is still largely unknown why lung cancer is becoming the commonest and deadliest of cancers.

Integration of high-throughput molecular data originating from mass spectrometry (proteomics) to those of next-generation sequencing (genomics, transcriptomics) are currently paving the way towards designating molecular causes of cancer tumorigenesis. Proteogenomics is increasingly becoming a valuable instrument for biomedical research. This type of research is important in the lung cancer setting, not only for understanding its epidemiology, but also for studying effective therapeutic strategies in clinical applications.

For this Special Issue, we invite authors to contribute original research articles, method papers, as well as review articles that address recent achievements in proteogenomics associated with lung cancer research.

Potential topics include but are not limited to the following:

  • Methods of genomic, transcriptomic, and proteomic data integration;
  • Bioinformatic tools towards metagenomics and metaproteomics;
  • Clinical lung cancer proteogenomics towards precision medicine;
  • Lung cancer multi-omics.

Dr. Thanasis Anagnostopoulos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung cancer
  • genomic
  • transcriptomic
  • bioinformatic tools
  • multi-omics

Published Papers (1 paper)

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17 pages, 2544 KiB  
Systematic Review
Lung Cancer Proteogenomics: Shaping the Future of Clinical Investigation
by Theofanis Vavilis, Maria Louiza Petre, Giannis Vatsellas, Alexandra Ainatzoglou, Eleni Stamoula, Athanasios Sachinidis, Malamatenia Lamprinou, Ioannis Dardalas, Ioannis N. Vamvakaris, Ioannis Gkiozos, Konstantinos N. Syrigos and Athanasios K. Anagnostopoulos
Cancers 2024, 16(6), 1236; https://doi.org/10.3390/cancers16061236 - 21 Mar 2024
Viewed by 1378
Abstract
Background: Lung cancer is associated with a high incidence of mortality worldwide. Molecular mechanisms governing the disease have been explored by genomic studies; however, several aspects remain elusive. The integration of genomic profiling with in-depth proteomic profiling has introduced a new dimension to [...] Read more.
Background: Lung cancer is associated with a high incidence of mortality worldwide. Molecular mechanisms governing the disease have been explored by genomic studies; however, several aspects remain elusive. The integration of genomic profiling with in-depth proteomic profiling has introduced a new dimension to lung cancer research, termed proteogenomics. The aim of this review article was to investigate proteogenomic approaches in lung cancer, focusing on how elucidation of proteogenomic features can evoke tangible clinical outcomes. Methods: A strict methodological approach was adopted for study selection and key article features included molecular attributes, tumor biomarkers, and major hallmarks involved in oncogenesis. Results: As a consensus, in all studies it becomes evident that proteogenomics is anticipated to fill significant knowledge gaps and assist in the discovery of novel treatment options. Genomic profiling unravels patient driver mutations, and exploration of downstream effects uncovers great variability in transcript and protein correlation. Also, emphasis is placed on defining proteogenomic traits of tumors of major histological classes, generating a diverse portrait of predictive markers and druggable targets. Conclusions: An up-to-date synthesis of landmark lung cancer proteogenomic studies is herein provided, underpinning the importance of proteogenomics in the landscape of personalized medicine for combating lung cancer. Full article
(This article belongs to the Special Issue Lung Cancer Proteogenomics: New Era, New Insights)
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