Clinical PET Studies in Neuro-Oncology (Volume II)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 1 December 2024 | Viewed by 1110

Special Issue Editor


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Guest Editor
1. Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU-Nancy, Université de Lorraine, F-54000 Nancy, France
2. IADI UMR 1254, INSERM, Université de Lorraine, F-54000 Nancy, France
Interests: PET imaging; amino-acid radiotracers; neuro-oncology; glioma
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Special Issue Information

Dear Colleagues,

PET imaging is currently recommended as an adjunct to MRI for the assessment of brain tumors. The present Special Issue will focus on PET brain tumor assessment at different stages of the disease, including initial diagnosis, treatment planification, and follow-up studies in clinical practice. All types of brain tumors will be covered, including glioma, brain metastases, meningioma, and primary cerebral lymphoma. Specific attention will be paid to clinical studies with translational research to monitor peptide receptor radionuclide therapy. All of the available PET radiotracers that are useful in neuro-oncology clinical practice will be welcome, including FDG, amino acid radiotracers, DOTATOC PET imaging, and TSPO imaging. The objective of this Special Issue is to provide a complete and comprehensive overview of the potential of PET imaging in neuro-oncology to neuro-oncologists, neurosurgeons, radiologists, and nuclear physicians.

Prof. Dr. Antoine Verger
Guest Editor

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Keywords

  • PET
  • neuro-oncology
  • glioma
  • meningioma
  • lymphoma
  • brain metastasis
  • amino acid radiotracer
  • peptide receptor radionuclide therapy
  • DOTATOC
  • FDG
  • TSPO

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Published Papers (1 paper)

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Research

10 pages, 2244 KiB  
Article
The Value of PET/CT in Particle Therapy Planning of Various Tumors with SSTR2 Receptor Expression: Comparative Interobserver Study
by Carola Lütgendorf-Caucig, Patricia Wieland, Eugen Hug, Birgit Flechl, Slavisa Tubin, Razvan Galalae, Petra Georg, Piero Fossati, Marta Mumot, Semi Harrabi, Irina Pradler and Maciej J. Pelak
Cancers 2024, 16(10), 1877; https://doi.org/10.3390/cancers16101877 - 15 May 2024
Viewed by 823
Abstract
The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47 anonymized patient cases including [...] Read more.
The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47 anonymized patient cases including 30 meningiomas, 12 PitNET and 5 SBPGL. Four independent observers were instructed to contour the macroscopic tumor volume on planning MRI and then reassess their volumes with the additional information from DOTA-PET/CT. The conformity between observers and reference volumes was assessed. In total, 46 cases (97.9%) were DOTA-avid and included in the final analysis. In eight cases, PET/CT additional tumor volume was identified that was not detected by MRI; these PET/CT findings were potentially critical for the treatment plan in four cases. For meningiomas, the interobserver and observer to reference volume conformity indices were higher with PET/CT. For PitNET, the volumes had higher conformity between observers with MRI. With regard to SBGDL, no significant trend towards conformity with the addition of PET/CT information was observed. DOTA PET/CT supports accurate tumor recognition in meningioma and PitNET and is recommended in SSTR2-expressing tumors planned for treatment with highly conformal radiation. Full article
(This article belongs to the Special Issue Clinical PET Studies in Neuro-Oncology (Volume II))
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