Advances in Circulating Tumor Cells as a Liquid Biopsy for Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 2999

Special Issue Editors


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Guest Editor
Centre for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia
Interests: liquid biopsies; ovarian cancer; melanoma

E-Mail
Guest Editor
Centre for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia
Interests: liquid biopsies; melanoma; lung cancer

Special Issue Information

Dear Colleagues,

Cancer-related deaths have been attributed to the metastatic spread of tumour cells from the primary lesion to distant organs. As dissemination mostly occurs through the blood, the detection and characterisation of circulating tumour cells (CTCs) have become promising areas of oncology research. In the last decade, studies on CTCs have provided important insights into their role in cancer dissemination and, as one of the pillars constituting “liquid biopsy”, their potential utility as a clinically useful biomarker for timely disease detection, treatment response and disease progression evaluation, elucidation of disease mechanisms, and therapeutic target identification for drug development.

This Special Issue invites experts to contribute original research articles, as well as review articles, that describe the recent advances in CTC research in various cancer types. Potential topics include, but are not limited to, the following:

  • New technologies and methods for the isolation and detection of CTCs;
  • New approaches to characterise CTC biology;
  • Genomics, transcriptomics, proteomics and/or epigenetic profiling of CTCs;
  • Latest findings in CTC research and clinical implementation in various cancer types.

Dr. Leslie Calapre
Dr. Aaron Beasley
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • circulating tumor cells
  • biology
  • liquid biopsy
  • cancer
  • clinical implementation

Published Papers (2 papers)

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Review

21 pages, 321 KiB  
Review
The Role of Circulating Tumor Cells as a Liquid Biopsy for Cancer: Advances, Biology, Technical Challenges, and Clinical Relevance
by Tyler A. Allen
Cancers 2024, 16(7), 1377; https://doi.org/10.3390/cancers16071377 - 31 Mar 2024
Viewed by 1125
Abstract
Cancer remains a leading cause of mortality worldwide, with metastasis significantly contributing to its lethality. The metastatic spread of tumor cells, primarily through the bloodstream, underscores the importance of circulating tumor cells (CTCs) in oncological research. As a critical component of liquid biopsies, [...] Read more.
Cancer remains a leading cause of mortality worldwide, with metastasis significantly contributing to its lethality. The metastatic spread of tumor cells, primarily through the bloodstream, underscores the importance of circulating tumor cells (CTCs) in oncological research. As a critical component of liquid biopsies, CTCs offer a non-invasive and dynamic window into tumor biology, providing invaluable insights into cancer dissemination, disease progression, and response to treatment. This review article delves into the recent advancements in CTC research, highlighting their emerging role as a biomarker in various cancer types. We explore the latest technologies and methods for CTC isolation and detection, alongside novel approaches to characterizing their biology through genomics, transcriptomics, proteomics, and epigenetic profiling. Additionally, we examine the clinical implementation of these findings, assessing how CTCs are transforming the landscape of cancer diagnosis, prognosis, and management. By offering a comprehensive overview of current developments and potential future directions, this review underscores the significance of CTCs in enhancing our understanding of cancer and in shaping personalized therapeutic strategies, particularly for patients with metastatic disease. Full article
(This article belongs to the Special Issue Advances in Circulating Tumor Cells as a Liquid Biopsy for Cancers)
23 pages, 2635 KiB  
Review
Advancements in Circulating Tumor Cell Research: Bridging Biology and Clinical Applications
by Philip Salu and Katie M. Reindl
Cancers 2024, 16(6), 1213; https://doi.org/10.3390/cancers16061213 - 20 Mar 2024
Cited by 1 | Viewed by 1053
Abstract
Circulating tumor cells (CTCs) are cells released from the primary and metastatic tumor and intravasate into the blood or lymphatic vessels, where they are transported to distant sites and act as seeds that initiate cancer metastases or the development of further lesions. Recent [...] Read more.
Circulating tumor cells (CTCs) are cells released from the primary and metastatic tumor and intravasate into the blood or lymphatic vessels, where they are transported to distant sites and act as seeds that initiate cancer metastases or the development of further lesions. Recent advances in CTC research have shown their relevance as prognostic markers for early and metastatic disease detection, predictive biomarkers for relapse, and response to medical intervention or therapy. The rapidly evolving landscape of CTC biology has opened new avenues for understanding cancer progression, metastasis, and treatment response. Additionally, translating these findings into clinical applications holds promise for improving cancer diagnostics, prognosis, and personalized therapeutic strategies. This review discusses the significance of CTCs in cancer research and their associated challenges. We explore recent developments in the detection and characterization of CTCs and their implications in cancer research and clinical practice. Full article
(This article belongs to the Special Issue Advances in Circulating Tumor Cells as a Liquid Biopsy for Cancers)
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