Clinicopathological Study of Gynecologic Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1039

Special Issue Editor


E-Mail Website
Guest Editor
Department of Gynecology & Obstetrics, Vita Salute San Raffaele University School of Medicine, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
Interests: cervical cancer; human papillomavirus; HPV; gynecologic oncology; preventive oncology; CIN; cervical intraepithelial neoplasia

Special Issue Information

Dear Colleagues,

Gynecological malignancies are a critical global challenge, as at present high mortality rates due to lack of early diagnosis are reported in many countries. In recent years, significant milestones have been achieved in terms of uncovering the biology and the natural history of neoplasms. For example, it is now known that understanding  the mechanisms of human papillomavirus can aid in the diagnosis and curing of different histological subtypes of cervical cancer. Additionally, genetic alterations play an important causal role in the development and progression of endometrial and ovarian cancers, and environmental factors, such as the genital microbiome, further exacerbate them. Given these findings, both biological and clinical research have increasingly focused on the identification and validation of biomolecular, pathological and omics parameters associated with the higher risk of cancer development in females; to an extent, such research has led to clinically relevant improvements in terms of persistence/recurrence rates and better survival rates. Therefore, in this Special Issue, we cordially invite submissions of original research and comprehensive review articles focusing on the promising results found in recent biological and clinical research which have the potential to improve clinical practice and patients’ treatment, thereby enhancing the management of female genital cancers.

Dr. Origoni Massimo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynecological oncology
  • gynaecological cancer
  • female cancer
  • uterine cancer
  • ovarian cancer
  • endometrial cancer
  • cancerogenesis
  • cancer biology
  • cell transformation
  • cancer pathology
  • cancer biology

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 566 KiB  
Article
Long-Term Follow-Up Outcomes in Women with In Situ/Microinvasive Adenocarcinoma of the Uterine Cervix Undergoing Conservative Treatment—Cervical Adenocarcinoma Study Group Italian Society of Colposcopy and Cervico-Vaginal Pathology
by Luca Giannella, Giovanni Delli Carpini, Jacopo Di Giuseppe, Camilla Grelloni, Giorgio Bogani, Marco Dri, Francesco Sopracordevole, Nicolò Clemente, Giorgio Giorda, Rosa De Vincenzo, Maria Teresa Evangelista, Barbara Gardella, Mattia Dominoni, Ermelinda Monti, Chiara Alessi, Lara Alessandrini, Angela Guerriero, Alessio Pagan, Marta Caretto, Alessandro Ghelardi, Andrea Amadori, Massimo Origoni, Maggiorino Barbero, Francesco Raspagliesi, Tommaso Simoncini, Paolo Vercellini, Arsenio Spinillo, Giovanni Scambia and Andrea Ciavattiniadd Show full author list remove Hide full author list
Cancers 2024, 16(6), 1241; https://doi.org/10.3390/cancers16061241 - 21 Mar 2024
Viewed by 853
Abstract
Objective: The present study aimed to assess long-term follow-up outcomes in women with in situ/microinvasive adenocarcinoma (AC) of the uterine cervix treated conservatively. Methods: Retrospective multi-institutional study including women with early glandular lesions and 5-year follow-up undergoing fertility-sparing treatment. Independent variables associated with [...] Read more.
Objective: The present study aimed to assess long-term follow-up outcomes in women with in situ/microinvasive adenocarcinoma (AC) of the uterine cervix treated conservatively. Methods: Retrospective multi-institutional study including women with early glandular lesions and 5-year follow-up undergoing fertility-sparing treatment. Independent variables associated with recurrence were evaluated. Logistic regression analysis and Kaplan–Meier survival analysis with Logrank test were performed. Results: Of 269 women diagnosed with in situ/microinvasive AC, 127 participants underwent conservative treatment. During follow-up, recurrences were found in nine women (7.1%). The only factor associated with recurrence during follow-up was positive high-risk Human Papillomavirus (hr-HPV) testing (odds ratio 6.21, confidence interval 1.47–26.08, p = 0.012). HPV positivity in follow-up showed a recurrence rate of 21.7% against 3.8% in patients who were HPV-negative (p = 0.002, Logrank test). Among women with negative high-risk HPV tests in follow-up, recurrences occurred in 20.0% of non-usual-type histology vs. 2.1% of usual-type cases (p = 0.005). Conclusion: HPV testing in follow-up is of pivotal importance in women with early glandular lesions undergoing conservative treatment, given its recurrence predictive value. However, women who are high-risk HPV-negative in follow-up with non-usual-type histopathology may represent a sub-population at increased risk of recurrences. Further studies should confirm these findings. Full article
(This article belongs to the Special Issue Clinicopathological Study of Gynecologic Cancer)
Show Figures

Figure 1

Back to TopTop