Molecular Alterations of Endometrial Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 2383

Special Issue Editors


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Guest Editor
Department of Gynecology, Lublin Medical University, 20-090 Lublin, Poland
Interests: endometrial cancer; molecular alterations; patients prognosis; endometrial hyperplasia

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Guest Editor
1. Department of Gynaecology, Maastricht University Medical Centre (MUMC), 6202 AZ Maastricht, The Netherlands
2. GROW—School for Oncology and Reproduction, Maastricht University, 6202 AZ Maastricht, The Netherlands
Interests: endometrial cancer; molecular alterations; patient prognosis; hormonal interactions
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Special Issue Information

Dear Colleagues,

Several pieces of data presented up to now have suggested a great influence of various genetic alterations during the development and subsequent spread of female genital tract carcinomas. Endometrial cancer (EC) is one of the leading female genital tract neoplasms worldwide, with over 400,000 new cases diagnosed annually worldwide. Unfortunately, both its incidence and mortality are slightly increasing. Molecular classification presented a few years ago identified four district subgroups of EC with various genetic/immunohistochemical alterations. This classification also has several clinical applications, both in treatment protocols as well as patient outcomes. Presently, we would like to invite all scientists investigating the role of molecular alterations in EC to share their results and knowledge by submitting their manuscripts to this Special Issue of the prestigious Cancers journal, entitled “Molecular Alterations of Endometrial Cancer”. The editors will do their best in fairly pre-reviewing all submissions, giving the chance to review and subsequently quickly publish the manuscripts with outstanding scientific achievements.  

Prof. Dr. Andrzej Semczuk
Dr. Andrea Romano
Guest Editors

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Keywords

  • endometrial cancer
  • molecular alterations
  • molecular classification
  • patient outcomes
  • endometrial hyperplasia
  • targeted therapy
  • genetic pathway
  • endometrial cancer subtypes

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Published Papers (1 paper)

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Review

28 pages, 819 KiB  
Review
Role of Estrogen Receptor β, G-Protein Coupled Estrogen Receptor and Estrogen-Related Receptors in Endometrial and Ovarian Cancer
by Susanne Schüler-Toprak, Maciej Skrzypczak, Carsten Gründker, Olaf Ortmann and Oliver Treeck
Cancers 2023, 15(10), 2845; https://doi.org/10.3390/cancers15102845 - 20 May 2023
Cited by 8 | Viewed by 2079
Abstract
Ovarian and endometrial cancers are affected by estrogens and their receptors. It has been long known that in different types of cancers, estrogens activate tumor cell proliferation via estrogen receptor α (ERα). In contrast, the role of ERs discovered later, including ERβ and [...] Read more.
Ovarian and endometrial cancers are affected by estrogens and their receptors. It has been long known that in different types of cancers, estrogens activate tumor cell proliferation via estrogen receptor α (ERα). In contrast, the role of ERs discovered later, including ERβ and G-protein-coupled ER (GPER1), in cancer is less well understood, but the current state of knowledge indicates them to have a considerable impact on both cancer development and progression. Moreover, estrogen related receptors (ERRs) have been reported to affect pathobiology of many tumor types. This article provides a summary and update of the current findings on the role of ERβ, GPER1, and ERRs in ovarian and endometrial cancer. For this purpose, original research articles on the role of ERβ, GPER1, and ERRs in ovarian and endometrial cancers listed in the PubMed database have been reviewed. Full article
(This article belongs to the Special Issue Molecular Alterations of Endometrial Cancer)
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