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Cancers
Special Issues
IECC2022: Tumor Microenvironment Heterogeneity in Cancer Progression: Challenge or Opportunity
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IECC2022: Tumor Microenvironment Heterogeneity in Cancer Progression: Challenge or Opportunity

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: closed (1 September 2023) | Viewed by 8447

Special Issue Editors

Prof. Dr. Samuel C. Mok

E-Mail Website
Guest Editor
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Interests: gynecologic cancers; tumor microenvironment; diagnostic and prognostic biomarkers discovery; stomal-epithelial interaction; exosomes
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Paola Cappello

E-Mail Website
Guest Editor
Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy
Interests: pancreatic tumor; identification of antigens as diagnostic markers and potential immunotherapeutic targets; DNA vaccination; inflammation and fibrosis
Special Issues, Collections and Topics in MDPI journals
Dr. Sammy Ferri-Borgogno

E-Mail Website
Guest Editor
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Interests: gynecologic oncology; reproductive medicine

Special Issue Information

Dear colleagues,

This Special Issue will comprise selected papers from the proceedings of the 2nd International Electronic Conference on Cancers: Tumor Microenvironment Heterogeneity in Cancer Progression: Challenge or Opportunity (IECC 2022) 14–16 February 2022, held on sciforum.net, an online platform for hosting scholarly e-conferences and discussion groups.

The focus of this conference is the translation of basic science understanding the tumor microenvironment and its dysregulation in cancer to its therapeutic exploitation, and is divided into twelve sessions, each with an invited keynote speaker and chair and short proffered talks on the following:

  • Tumor Heterogeneity and Chemoresistance
  • Tumor Heterogeneity and Immune Evasion
  • Clonal Evolution and Tumor Heterogeneity
  • Technological Platforms for Tumor and TME Heterogeneity Studies
  • Novel Computational Approaches in Tumor Analyses
  • Proteomics and Metabolomics to Dissect Tumor Tissue Heterogeneity
  • Targeting Tumor Microenvironment as Therapeutical Strategy to Hit Cancer: News from the Lab
  • Pre-Clinical Models to Study Cancer Heterogeneity: Emerging Technologies
  • Immunotherapy: Strategies to Unleash the Anti-Tumor Response

Selected papers that attract the most interest on the web or that provide a particularly innovative contribution will be selected for publication. These papers will be subjected to peer review and published with the aim of rapid and wide dissemination of research results, developments, and applications. We hope that this Conference Series will continue to grow in acceptance and recognition among potential participants, contributors, experts who want to disseminate their latest findings, and readers who seek information on tumor microenvironment heterogeneity in cancer progression.

Prof. Dr. Samuel C. Mok
Prof. Dr. Paola Cappello
Dr. Sammy Ferri-Borgogno
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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14 pages, 759 KiB  
Review
Strategies for Efficient Targeting of Tumor Collagen for Cancer Therapy
by Silvia Baldari, Francesca Di Modugno, Paola Nisticò and Gabriele Toietta
Cancers 2022, 14(19), 4706; https://doi.org/10.3390/cancers14194706 - 27 Sep 2022
Cited by 8 | Viewed by 3774
Abstract
The tumor stroma, which comprises stromal cells and non-cellular elements, is a critical component of the tumor microenvironment (TME). The dynamic interactions between the tumor cells and the stroma may promote tumor progression and metastasis and dictate resistance to established cancer therapies. Therefore, [...] Read more.
The tumor stroma, which comprises stromal cells and non-cellular elements, is a critical component of the tumor microenvironment (TME). The dynamic interactions between the tumor cells and the stroma may promote tumor progression and metastasis and dictate resistance to established cancer therapies. Therefore, novel antitumor approaches should combine anticancer and anti-stroma strategies targeting dysregulated tumor extracellular matrix (ECM). ECM remodeling is a hallmark of solid tumors, leading to extensive biochemical and biomechanical changes, affecting cell signaling and tumor tissue three-dimensional architecture. Increased deposition of fibrillar collagen is the most distinctive alteration of the tumor ECM. Consequently, several anticancer therapeutic strategies have been developed to reduce excessive tumor collagen deposition. Herein, we provide an overview of the current advances and challenges of the main approaches aiming at tumor collagen normalization, which include targeted anticancer drug delivery, promotion of degradation, modulation of structure and biosynthesis of collagen, and targeting cancer-associated fibroblasts, which are the major extracellular matrix producers. Full article
(This article belongs to the Special Issue IECC2022: Tumor Microenvironment Heterogeneity in Cancer Progression: Challenge or Opportunity)
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17 pages, 865 KiB  
Review
Recent Advances in CAR T-Cell Therapy for Patients with Chronic Lymphocytic Leukemia
by Benjamin M. Heyman, Dimitrios Tzachanis and Thomas J. Kipps
Cancers 2022, 14(7), 1715; https://doi.org/10.3390/cancers14071715 - 28 Mar 2022
Cited by 9 | Viewed by 3008
Abstract
Chimeric antigen receptor T cells (CAR T cells) have resulted in dramatic treatment responses for patients with hematologic malignancies, resulting in improved survival for patients with intractable disease. The first patient treated with CD19 directed CAR T cell therapy had chronic lymphocytic leukemia [...] Read more.
Chimeric antigen receptor T cells (CAR T cells) have resulted in dramatic treatment responses for patients with hematologic malignancies, resulting in improved survival for patients with intractable disease. The first patient treated with CD19 directed CAR T cell therapy had chronic lymphocytic leukemia (CLL) and achieved a complete remission. Subsequent clinical trials have focused largely on patients with other B-cell hematologic malignancies, owing to the fact that CAR T cell therapy for patients with CLL has met with challenges. More recent clinical trials have demonstrated CAR T cell therapy can be well tolerated and effective for patients with CLL, making it a potential treatment option for patients with this disease. In this article we review the background on CAR T cells for the treatment of patients with CLL, focusing on the unique obstacles that patients with CLL present for the development of adoptive T cell therapy, and the novel approaches currently under development to overcome these hurdles. Full article
(This article belongs to the Special Issue IECC2022: Tumor Microenvironment Heterogeneity in Cancer Progression: Challenge or Opportunity)
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