Recent Advances in the Understanding of Myelodysplastic Syndrome and Acute Myeloid Leukemia
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: closed (28 October 2024) | Viewed by 27074
Special Issue Editors
Interests: hematopoietic stem cells; hematopoietic stem cell niche; myelopoiesis; neutrophils; neutrophil extracellular traps; thrombosis; myelodysplastic syndrome
Interests: myelodysplastic syndrome; hematopoietic stem cell transplantation
Interests: hematologic malignancies; thrombosis; complement; cellular therapy; lymphoma; myeloma; COVID-19
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Special Issue Information
Dear Colleagues,
During recent decades, significant progress has been made in the molecular characterization of myeloid malignancies, including myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), and myeloproliferative neoplasms (MPN). The technological progress made the identification of several driver mutations feasible, which paves the road for a personalized approach in the diagnosis and treatment of these disorders, as well as in the introduction of targeted therapies in the clinical practice.
Despite the fundamental discoveries in deciphering the genetic basis of myeloid malignancies and the interaction between clonal cells and the bone marrow micro-environment, the treatment of this disorder remained until recently unchanged. For instance, the treatment of patients with low-risk MDS is still largely supportive, using growth factors and transfusions to improve the symptoms of the disease, whereas hypomethylating agents are used in the treatment of older patients with advanced MDS and AML. Based on the aging population, the prevalence of these disorders is expected to increase in the following years.
The aim of this Special Issue is to discuss recent findings in the epidemiology, treatment, and pathogenesis of MDS and AML. Epidemiological studies, clinical trials involving the introduction of novel treatment strategies in MDS and AML, original translational research articles and reviews are welcome in this Special Issue.
We look forward to receiving your contributions.
Dr. Ioannis Mitroulis
Dr. Konstantinos Liapis
Dr. Eleni Gavriilaki
Guest Editors
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Keywords
- myelodysplastic syndrome
- acute myeloid leukemia
- bone marrow microenvironment
- targeted therapies
- hematopoietic stem cell
- leukemic stem cell
- hematopoietic stem cell transplantation
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