RAS Signaling Pathway in Cancer Therapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 5 January 2025 | Viewed by 10712
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mutations in one of the RAS genes are found in a quarter of all human cancers. Since their discovery, researchers have attempted to develop therapeutic strategies to inhibit RAS oncoproteins, either directly or indirectly; however, it was not until 2021 that the first inhibitor that blocks one of the mutant isoforms of KRAS (KRASG12C) in its inactive state was finally approved. Moreover, other strategies are currently being developed, including those that inhibit this oncoprotein in its active form or approaches to target other mutant isoforms. Given that RAS signaling plays a critical role in several cellular activities such as cell proliferation, a deeper understanding of RAS signaling in cancer, but also in development or homeostasis, is urgently required to further improve the therapeutic options for patients with tumors harboring RAS mutations.
The scope of this Special Issue is to further advance our understanding of the unique requirements for RAS signaling in distinct contexts such as tumor initiation, growth, or maintenance. Genetic studies in particular, although not exclusively, have the potential to uncover novel vulnerabilities that may ultimately expand the therapeutic options for patients with acquired or even intrinsic resistance. More importantly, genetic studies can also provide knowledge regarding essential requirements for RAS signaling in more universal contexts, with the final goal being to keep the therapy-related toxicities as low as possible.
Dr. Matthias Drosten
Guest Editor
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Keywords
- RAS signaling
- MAPK pathway
- RAS effectors
- KRAS inhibitors
- resistance
- drug combinations
- tumor growth mechanisms
- signaling pathways
- toxicity
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