Multiple Signaling Pathways in Ovarian Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 7192
Special Issue Editors
Interests: ovarian cancer; epithelial mesenchymal transition; immune modulation; immune therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ovarian cancer is the fourth leading cause of cancer-related death in women in the United States and is the leading cause of gynecological cancer death. The high rate of mortality reflects the poorly understood preclinical state of ovarian cancer and the lack of specific symptoms.
Approximately 80% of patients with primary disease respond to surgery and chemotherapy; however, the number of responders decreases to ~15% for recurrent cancers. Individuals who succumb to advanced-stage ovarian cancer inevitably become refractory to chemotherapy, resulting in disease progression and death. The two major reasons for the poor prognosis of this disease are metastasis and chemoresistance.
Many of the signaling pathways activated in the cancer cells originate in the tumor microenvironment and play different roles during malignant transformation. Contrary to other solid tumors, the ovarian cancer microenvironment comprises the peritoneal cavity and the factors secreted by the different tissues and cells, including adipocyte cells, mesothelial cells, immune cells, and tissue fibroblasts, which will impact the response and behavior of malignant cells. This Special Issue will highlight the current state of the art in terms of the molecular signals originating from the tumor microenvironment that regulate malignant cells’ transformation, metastatic potential, and chemoresistance.
Scope: Molecular pathways responsible for mesenchymal transformation and chemoresistance.
Aims: This Special Issue aims to provide a platform for new findings related to the tumor microenvironment and the molecular pathways associated with ovarian cancer progression and chemoresistance. In this Special Issue, both original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Molecular signals originating from the tumor microenvironment responsible for the process of mesenchymal transformation;
- The role of exosomes in the transformation of ovarian cancer cells;
- The influence of the stroma on malignant progression;
- Adipocytes and their role in malignant progression;
- Metabolic adaptation and pathways conferring mesenchymal transformation;
- The role of the signals initiated in the microenvironment responsible for chemoresistance;
- Inflammatory signals and malignant progression.
Dr. Gil Mor
Prof. Dr. Ayesha B. Alvero
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- ovarian cancer
- chemoresistance
- epithelial mesenchymal transformation
- metastasis
- signaling pathways
- immune modulation
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