Educating Recent Updates on Metastatic Non-small Cell Lung Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 778

Special Issue Editors


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Guest Editor
Department of Tumor Biology and GI Oncology, H. Lee Moffitt Cancer Center and Research Institute, 1209 USF Magnolia Drive, Tampa, FL 33612, USA
Interests: non-small cell lung cancer; lung adenocarcinoma; pancreatic ductal adenocarcinoma; tumor microenvironment; cancer metastasis; cancer epigenetics; post-translational modification of proteins

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Guest Editor
Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh, India
Interests: stem cells/cancer stem cells; non-coding RNAs; therapy resistance cancer; transgenesis
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Special Issue Information

Dear Colleagues,

Recent updates on metastatic non-small cell lung cancer (NSCLC) delve into intricate aspects of lung adenocarcinomas and squamous cell carcinomas, investigating tumor microenvironment dynamics, epithelial to mesenchymal transition, and the role of desmoplasia towards lung cancer metastasis. Exploring tumor matrix biology, epigenetic modulation influencing tumor metastasis, and/or post-translational modifications of certain key tumorigenic factors adds depth to understanding the progression of cancer. Additionally, insights into the failure of immune surveillance mechanisms facilitating immune escape give a comprehensive understanding of the disease. Collectively, these recent findings in the field will enhance our grasp on the molecular intricacies driving metastatic NSCLC, paving the possible way for future advancements in the diagnosis of the disease and therapy.

Dr. Biswarup Saha
Dr. Hifzur R Siddique
Guest Editors

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Keywords

  • non-small cell lung cancer
  • lung adenocarcinoma
  • lung squamous cell carcinoma
  • tumor microenvironment (TME)
  • epithelial to mesenchymal transition (EMT)
  • cancer metastasis
  • desmoplasia
  • tumor matrix biology
  • epigenetic modulations leading cancer metastasis
  • post-translational modifications (PTMs)
  • immune evasion

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Published Papers (1 paper)

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Research

13 pages, 1391 KiB  
Article
Comparative Efficacy of Adagrasib and Sotorasib in KRAS G12C-Mutant NSCLC: Insights from Pivotal Trials
by Tzu-Rong Peng, Ta-Wei Wu, Tai-Yung Yi and An-Jan Wu
Cancers 2024, 16(21), 3676; https://doi.org/10.3390/cancers16213676 - 30 Oct 2024
Viewed by 199
Abstract
Background: The KRAS G12C mutation, prevalent in various malignancies, including non-small cell lung cancer (NSCLC), represents a unique therapeutic target. Adagrasib and sotorasib, two FDA-approved agents specifically targeting this mutation, have shown promise in clinical trials. This study aims to compare their [...] Read more.
Background: The KRAS G12C mutation, prevalent in various malignancies, including non-small cell lung cancer (NSCLC), represents a unique therapeutic target. Adagrasib and sotorasib, two FDA-approved agents specifically targeting this mutation, have shown promise in clinical trials. This study aims to compare their efficacy in treating KRAS G12C-mutated NSCLC, drawing insights from pivotal clinical trials. Methods: We analyzed data from three key clinical trials: KRYSTAL-1, CodeBreak100, and CodeBreak200. Our methodology involved reconstructing individual patient data from published Kaplan–Meier curves using the IPDfromKM tool (Version 0.1.10). The primary endpoints were progression-free survival (PFS) and overall survival (OS), evaluated through hazard ratios (HRs) and the restricted mean survival time (RMST) method. Results: The HR for PFS favored adagrasib (HR: 0.90 [95% CI: 0.69, 1.19], p = 0.473), suggesting a non-significant trend toward better disease control compared to sotorasib. For OS, the HR was 0.99 [95% CI: 0.75, 1.33] (p = 0.969), indicating no significant difference between the two drugs. RMST analysis supported these findings, with adagrasib showing a consistently higher RMST in PFS at 6, 12, and 18 months. However, OS benefits converged over time, with adagrasib marginally surpassing sotorasib by the 18-month mark. Conclusions: This comprehensive analysis reveals that while adagrasib may offer a slight advantage in PFS, both drugs demonstrate comparable efficacy in OS for KRAS G12C-mutated NSCLC. The subtle differences observed, particularly in PFS, could inform clinical decision-making, emphasizing the need for personalized treatment strategies. Future research should focus on long-term effects and identifying patient subgroups that may benefit more from one drug over the other. Full article
(This article belongs to the Special Issue Educating Recent Updates on Metastatic Non-small Cell Lung Cancer)
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