The Role of Ferroptosis in Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1039

Special Issue Editor


E-Mail Website
Guest Editor
Department of Pediatrics, Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA, USA
Interests: hippo pathway; brain tumor; tumor microenvironment; ferroptosis; regulated cell death

Special Issue Information

Dear Colleagues,

Ferroptosis is a type of regulated cell death (RCD) that depends on iron and is caused by lethal accumulation of intracellular lipid peroxides. Since it was discovered more than a decade ago, studies have found that tumor cells, while able to resist other types of therapy-induced cell death, such as apoptosis, are sensitive to ferroptosis. These different responses led people to examine the therapeutic benefit of eliminating tumor cells through ferroptosis. Accumulating evidence has been emerging to support this notion. On the other hand, ferroptotic cells, through releasing damage-associated molecular patterns (DAMPs) or other metabolites, could alter the tumor microenvironment, especially immune cells. This effect could be associated with enhanced immunogenicity; however, in certain situations, it may lead to sustained inflammation and have an immunosuppressive impact, thereby promoting tumor progression and therapeutic resistance. How to exploit ferroptosis to benefit cancer therapy while circumventing the potential tumor promotion effect is under intense study.

This Special Issue will highlight the latest advances in basic and translational research of ferroptosis in cancer, aiming to accelerate the speed in exploiting ferroptosis for cancer treatment.

Dr. Wei Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ferroptosis
  • cancer
  • reactive oxygen species
  • ROS
  • regulated cell death
  • RCD
  • immunogenic cell death
  • ICD
  • immunosuppression

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

19 pages, 4025 KiB  
Review
Inorganic Nanomedicine—Mediated Ferroptosis: A Synergistic Approach to Combined Cancer Therapies and Immunotherapy
by Adityanarayan Mohapatra, Ayeskanta Mohanty and In-Kyu Park
Cancers 2024, 16(18), 3210; https://doi.org/10.3390/cancers16183210 - 20 Sep 2024
Viewed by 687
Abstract
Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, has generated substantial interest in cancer therapy. Various methods have been developed to induce ferroptosis in tumor cells, including approved drugs, experimental compounds, and nanomedicine formulations. Unlike apoptosis, ferroptosis presents unique [...] Read more.
Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, has generated substantial interest in cancer therapy. Various methods have been developed to induce ferroptosis in tumor cells, including approved drugs, experimental compounds, and nanomedicine formulations. Unlike apoptosis, ferroptosis presents unique molecular and cellular features, representing a promising approach for cancers resistant to conventional treatments. Recent research indicates a strong link between ferroptosis and the tumor immune microenvironment, suggesting the potential of ferroptosis to trigger robust antitumor immune responses. Multiple cellular metabolic pathways control ferroptosis, including iron, lipid, and redox metabolism. Thus, understanding the interaction between tumor metabolism and ferroptosis is crucial for developing effective anticancer therapies. This review provides an in-depth discussion on combining inorganic nanoparticles with cancer therapies such as phototherapy, chemotherapy, radiotherapy, and immunotherapy, and the role of ferroptosis in these combination treatments. Furthermore, this paper explores the future of tumor treatment using nanomedicine, focusing on how inorganic nanoparticles can enhance ferroptosis in tumor cells and boost antitumor immunity. The goal is to advance ferroptosis-based nanomedicine from the laboratory to clinical applications. Full article
(This article belongs to the Special Issue The Role of Ferroptosis in Cancer)
Show Figures

Figure 1

Back to TopTop