The Role of Ferroptosis in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 1039
Special Issue Editor
Special Issue Information
Dear Colleagues,
Ferroptosis is a type of regulated cell death (RCD) that depends on iron and is caused by lethal accumulation of intracellular lipid peroxides. Since it was discovered more than a decade ago, studies have found that tumor cells, while able to resist other types of therapy-induced cell death, such as apoptosis, are sensitive to ferroptosis. These different responses led people to examine the therapeutic benefit of eliminating tumor cells through ferroptosis. Accumulating evidence has been emerging to support this notion. On the other hand, ferroptotic cells, through releasing damage-associated molecular patterns (DAMPs) or other metabolites, could alter the tumor microenvironment, especially immune cells. This effect could be associated with enhanced immunogenicity; however, in certain situations, it may lead to sustained inflammation and have an immunosuppressive impact, thereby promoting tumor progression and therapeutic resistance. How to exploit ferroptosis to benefit cancer therapy while circumventing the potential tumor promotion effect is under intense study.
This Special Issue will highlight the latest advances in basic and translational research of ferroptosis in cancer, aiming to accelerate the speed in exploiting ferroptosis for cancer treatment.
Dr. Wei Li
Guest Editor
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Keywords
- ferroptosis
- cancer
- reactive oxygen species
- ROS
- regulated cell death
- RCD
- immunogenic cell death
- ICD
- immunosuppression
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