Special Issue "Matrix Metalloproteinases in Cancer Progress"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (15 December 2013)
Prof. Dr. Constance E. Brinckerhoff (Website)
Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Rubin 602, 1 Medical Center Drive, Lebanon, NH 03756, USA
Interests: melanoma, breast cancer, lung cancer, signal transduction, protease activated receptor-1 (par-1); angiogenesis, mmp-1, transcription, gene expression
The importance of MMPs in connective tissue remodeling and matrix degradation have been known for a long time. Increasingly, it is recognized that these enzymes have critical roles in signal transduction and gene regulation, and that they may have beneficial functions in normal homeostasis as well as in diseases. This special issue is dedicated to highlighting the more novel and innovative roles of secreted MMPs and their membrane bound counterparts, MT-MMPs, as mediators of cancer progression and as tumor suppressors. In addition, these enzymes may participate in cancers by functioning in organelles, such as exosomes and invadopodia. Thus, with their ubiquitous presence, they continue to represent attractive therapeutic targets and new strategies with improved efficacy are emerging. Finally, innovative models of cancers, such as zebrafish, may provide critical insights into how MMPs contribute to cancer progression.
Prof. Dr. Constance E. Brinckerhoff
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed Open Access monthly journal published by MDPI.
- novel roles of MMPs in tumor progression and suppression
- gene regulation
- signal transduction
- model systems
- therapeutic strategies