Role of Innate Immunity in Chronic Kidney Diseases—Series 2

Dear colleagues,

We are pleased to announce the second edition of our Special Issue. The first edition attracted the interest of researchers from around the world. The publications, which you are freely available to download, are listed at the link below:

Cells website: https://www.mdpi.com/journal/cells/special_issues/R897RE8S38.

Chronic kidney disease (CKD) is a worldwide health problem, with a global estimated prevalence of 16% and costs of USD 7.1 million for renal replacement therapy for patients with end-stage kidney disease. Among the multiple pathogenic mechanisms responsible for CKD, deregulated inflammation, oxidative stress, and immune system activation have deserved significant attention in recent years. More precisely, sterile inflammation triggered by the activation of the innate immune system has been shown to be an important driver of CKD. While our understanding of the innate immune system’s components and ligands, as well as its activation and regulation, has substantially improved in recent years, finding new drug targets and implementations of anti-inflammatory treatments for patients with CKD remains a challenge. This Special Issue will focus on different aspects of innate immunity involvement in CKD development and progression, including molecular, biochemical, and physiological mechanisms. We welcome original basic research and review articles related to the role of innate immunity in CKD.

Dr. Alla Mitrofanova
Guest Editor

Manuscript Submission Information

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• CKD
• glomeruli
• tubules
• sterile inflammation
• innate immunity
• pattern recognition receptors (PRRs)
• damage-associated molecular patterns (DAMPs)
• STING
• toll-like receptors
• RIG-I
• NLRP