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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies

edited by

Qiwei Wang

submission deadline 25 Jan 2026 | 4 articles | Viewed by 2525

Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies

(This special issue belongs to the Section Cellular Immunology)

Soluble Interleukin-6 Receptor (sIL-6R): Role in Health and Disease

edited by

Rebecca Aicheler

and

Richard Webb

submission deadline 25 Jan 2026 | 1 articles | Viewed by 2390

Keywords: sIL-6R; IL-6 signalling; IL-6ST; genetic polymorphism; health; disease; exercise physiology; therapeutics; mental health

(This special issue belongs to the Section Cell Signaling)

The Role of T Cells in Type 1 Diabetes

edited by

Ismail Syed

and

Mayur S. Parmar

submission deadline 25 Jan 2026 | Viewed by 611

Keywords: T cells; inflammation; T cell receptor; type 1 diabetes

(This special issue belongs to the Section Cellular Immunology)

Targeting Immune Dysfunction in Aging and Age-Related Diseases

edited by

Anna Aiello

and

Anna Calabrò

submission deadline 25 Jan 2026 | Viewed by 276

Keywords: immunosenescence; inflammaging; immune dysfunction; aging; age-related diseases (ARDs); immune– metabolic interactions; immunomodulators; immunoceuticals; senotherapeutics; lifestyle interventions

Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms

edited by Masmoudi-Kouki Olfa and

Gérard Lizard

submission deadline 25 Jan 2026 | Viewed by 231

Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling

(This special issue belongs to the Section Stem Cells)

The Developments and Applications of Vibrational Spectroscopy in Cellular Research

edited by

Maria Lasalvia

submission deadline 25 Jan 2026 | Viewed by 116

Keywords: vibrational spectroscopy; FT-IR spectroscopy; Raman spectroscopy; biomedical diagnostics; cancer research; Alzheimer’ s disease; neurodegeneration; tissue engineering; spectroscopic biomarkers; label-free imaging

(This special issue belongs to the Section Cell Methods)

The Roles of the Extracellular Matrix in Cardiac Structure and Function: A Commemorative Issue in Honor of Dr. Thomas K. Borg

edited by

Wayne Carver

and Edie Goldsmith

submission deadline 30 Jan 2026 | 8 articles | Viewed by 8935 | Submission Open

Keywords: collagen; integrin; extracellular matrix; cardiomyocyte; fibroblast; heart bioengineering

(This special issue belongs to the Section Cell Microenvironment)

Mechanisms Underlying Cardiovascular Aging

edited by Soheil Saeedi

submission deadline 30 Jan 2026 | 2 articles | Viewed by 4024 | Submission Open

Keywords: cardiovascular aging; cellular senescence; epigenetic clock; endothelial cells; perivascular adipose tissue (PVAT); premature aging; senolytics; rejuvenating strategies

(This special issue belongs to the Section Cells of the Cardiovascular System)

Stem Cells, Disease Mechanisms, and Therapeutic Innovations in Breast and Endometrial Disorders

edited by

Walid Shaalan

, Benedikt Schaefgen and

Nourhan Hassan

submission deadline 30 Jan 2026 | Viewed by 405 | Submission Open

Keywords: endometrial stem cells; breast cancer; endometrial diseases; tumor microenvironment; matrix remodeling; regenerative medicine; bioengineering; stem cell therapy; molecular pathogenesis; disease modeling

(This special issue belongs to the Section Stem Cells)

Tumor Immune Responsiveness in the Era of T Cell Immunotherapy

edited by

Xin Li

and

Wenjian Wang

submission deadline 30 Jan 2026 | Viewed by 312 | Submission Open

Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation

Advanced Technology for Cellular Imaging

edited by Alessandro Grinzato,

Vittoria Raimondi

and

J. Bernard Heymann

submission deadline 31 Jan 2026 | 9 articles | Viewed by 23795 | Submission Open

Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction

(This special issue belongs to the Section Cell Methods)

Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases

edited by

Prathapan Ayyappan

submission deadline 31 Jan 2026 | 7 articles | Viewed by 23067 | Submission Open

Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods

(This special issue belongs to the Section Cells of the Cardiovascular System)

Neuroinflammation in Brain Health and Diseases

edited by Debashis Dutta and Nemil Bhatt

submission deadline 31 Jan 2026 | 10 articles | Viewed by 21530 | Submission Open

Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics

(This special issue belongs to the Section Cellular Neuroscience)

Imaging Methods in Cell Biology

edited by

Claudia Moscheni

and

Nicoletta Gagliano

submission deadline 31 Jan 2026 | 6 articles | Viewed by 17929 | Submission Open

Keywords: cellular organelles; molecular function; molecular interaction; disease- and drug-related subcellular phenomena; single-molecule imaging; light microscopy; electron microscopy; fluorescence microscopy; fluorescence correlation methods; fluorescence lifetime imaging microscopy (FLIM); Raman microscopy; spatial biology

(This special issue belongs to the Section Cell Methods)

Cancer-Associated Fibroblasts: Challenges and Directions

edited by

Paul J. Higgins

and

Ramesh Mukkamala

submission deadline 31 Jan 2026 | 5 articles | Viewed by 17529 | Submission Open

Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents

(This special issue belongs to the Section Cell Microenvironment)

CRISPR-Based Genome Editing in Translational Research—Third Edition

edited by

Jie Xu

Dongshan Yang

and Jifeng Zhang

submission deadline 31 Jan 2026 | 5 articles | Viewed by 8698 | Submission Open

Keywords: genome; gene editing; CRISPR/Cas9

Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance

edited by

Xinyu Wang

Lei Zhu

and Yuancheng Li

submission deadline 31 Jan 2026 | 4 articles | Viewed by 8061 | Submission Open

Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product

(This special issue belongs to the Section Cell Microenvironment)

Renewing Reasons to Believe in Gene Therapies for Epilepsy

edited by Casper Gøtzsche

submission deadline 31 Jan 2026 | 2 articles | Viewed by 7691 | Submission Open

Keywords: epilepsy; seizure; gene therapy; gene editing; disease modification; transformative; unmet need

(This special issue belongs to the Section Cellular Neuroscience)

Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy

edited by

Javier S. Castresana

submission deadline 31 Jan 2026 | 2 articles | Viewed by 5329 | Submission Open

Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy

(This special issue belongs to the Section Stem Cells)

Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases

edited by Patricia Morcillo

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2651 | Submission Open

Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers

(This special issue belongs to the Section Cellular Aging)

Cell Behavior Under Blood Flow

edited by Alexander Gural, Ivana Pajic-Lijakovic and

Gregory Barshtein

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2189 | Submission Open

Keywords: blood flow; shear stress; red blood cells; white blood cells; platelets; endothelial cells; cell stimulation; mechanical stress

The Role of Macrophages in Leishmaniasis: Current Perspective

edited by Devki Nandan

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1147 | Submission Open

Keywords: Leishmania; leishmaniasis; macrophage biology; host– pathogen interactions

Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond

edited by Valeria Gerbino

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1111 | Submission Open

Keywords: autophagy; neurodegeneration; amyotrophic lateral sclerosis (ALS); protein aggregation; cellular homeostasis; lysosomal dysfunction; neuronal health; therapeutic targets; molecular pathways; neuroprotective strategies

(This special issue belongs to the Section Cellular Neuroscience)

Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities

edited by Fabio Guolo

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1095 | Submission Open

Keywords: acute myeloid leukemia (AML); hematologic malignancy; AML classification; myeloid precursors; hematopoiesis; high-risk AML; biomarkers

(This special issue belongs to the Section Cellular Immunology)

Single-Molecule Tracking for Live Cells

edited by

Zeno Földes-Papp

submission deadline 31 Jan 2026 | Viewed by 463 | Submission Open

Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory

Diagnostic and Therapeutic Application of Extracellular Vesicles (EV)

edited by

Maria Magdalena Barreca

and

Chiara Corrado

submission deadline 31 Jan 2026 | Viewed by 364 | Submission Open

Keywords: extracellular vesicles (EVs); diseases biomarkers; therapeutic targets; drugs delivery; engineered extracellular vesicles; EVs therapeutic applications

Mechanisms That Link Olfactory Perception with Aging

edited by

Tuhin Subhra Chakraborty

, Anindya Ganguly and Jordan A. Munroe

submission deadline 31 Jan 2026 | Viewed by 352 | Submission Open

Keywords: olfaction; aging; neuroscience

(This special issue belongs to the Section Cellular Aging)

Human Organoids: A New Frontier in Disease Modeling

edited by

Priyanka Verma

and Umesh Kumar

submission deadline 31 Jan 2026 | Viewed by 342 | Submission Open

Keywords: 3D organ culture; embryonic stem cells; induced pluripotent stem cells; 3D bioprinting; personalized medicine; regenerative medicine

(This special issue belongs to the Section Tissues and Organs)

Gastrointestinal Disorders: Immunity and Inflammation

edited by Faizan Ahmed and

Aditi Bhargava

submission deadline 31 Jan 2026 | Viewed by 272 | Submission Open

Keywords: gastrointestinal disorders; immunity; inflammation; immune system; microbiota; gastroenterology; biomarkers; pathways

Genetics and Gene Regulation

edited by

Yujing Li

and

Han Yang

submission deadline 31 Jan 2026 | 1 articles | Viewed by 261 | Submission Open

Keywords: genetics; gene regulation; human diseases

Function of Stress Granules in Normal Cells and in Alzheimer’s Disease

edited by

Paul D. Coleman

and Benjamin Wolozin

submission deadline 31 Jan 2026 | Viewed by 209 | Submission Open

Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases

(This special issue belongs to the Section Cellular Aging)

New Perspectives of Respiratory Diseases: From Microbiome, Metabolism, and Immune Response

edited by

Bernhard Ryffel

submission deadline 31 Jan 2026 | Viewed by 207 | Submission Open

Keywords: cell death/stress; DNA/RNA sensor; cGAS/STING; inflammasome; microbiome; FMT or transfer of bacteria; metabolite; viral infection; emphysema; progressive fibrosis; innate immune response; defined inhibitors

Examining the Cellular Biology of Adenovirus

edited by Susan J. Morris, Adam C. T. Gillman and Erwan Sallard

submission deadline 31 Jan 2026 | Viewed by 188 | Submission Open

Keywords: adenovirus; replication; maturation; transduction; tropism; intracellular trafficking; targeting; virus– host interactions; transcriptome

The Language of Neural Cells: Decoding Molecular Signaling in Neurodevelopmental and Neuro-Oncological Disorders

edited by

Marilena Briglia

Alice Foti

and Adriana C. E. Graziano

submission deadline 31 Jan 2026 | Viewed by 178 | Submission Open

Keywords: neural cells; molecular signaling; neurodevelopmental disorders; neuro-oncological disorders; transcriptional dysregulation

(This special issue belongs to the Section Cellular Neuroscience)

Role of Oxidative Stress in Cardiovascular Diseases

edited by

Nevena Jeremic

and

Vladimir Jakovljevic

submission deadline 31 Jan 2026 | Viewed by 165 | Submission Open

Keywords: oxidative stress; reactive oxygen species (ROS); endothelial dysfunction; inflammation; cardiovascular pathology

(This special issue belongs to the Section Cells of the Cardiovascular System)

Advances in the Role of Lipid Signaling in Diseases

edited by

Roger Schneiter

and

Neng Wan

submission deadline 5 Feb 2026 | Viewed by 276 | Submission Open

Keywords: lipid signaling; membrane lipid dynamics; autophagy; disease pathology; mitochondria; transcription; protein degradation

Role of Alpha-Synuclein in Neurodegenerative Diseases

edited by

Carmela Conte

submission deadline 10 Feb 2026 | 1 articles | Viewed by 1862 | Submission Open

Keywords: Alpha-; Beta-; and Gamma-synuclein; synucleinopathies; neurodegeneration; neuroinflammation; authophagy; Parkinson's disease; non-motor symptoms; Alzheimer's disease; multiple system atrophy; psychiatric diseases

(This special issue belongs to the Section Cellular Aging)

Decoding Cellular Organization Through Spatial Omics

edited by Elizabeth Neumann

submission deadline 10 Feb 2026 | Viewed by 224 | Submission Open

Keywords: spatial proteomics; lipomics; cellular architecture; biomolecular interactions; bioinformatics; integrative biology

Exclusive Review Papers in Autophagy—Second Edition

edited by

Harald W. Platta

submission deadline 15 Feb 2026 | 4 articles | Viewed by 21916 | Submission Open

Keywords: biquitination; autophagy; peroxisomes; macroautophagy; pexophagy; mitophagy; lysosome; vacuole; organellar homeostasis; posttranslational modifications; lipids; signaling cascades

(This special issue belongs to the Section Autophagy)

Cancer Immunotherapy Harnessing Innate and Adaptive Immune Effector Cells and PD-1 Immune Checkpoint Inhibitors

edited by

Yoshimasa Tanaka

submission deadline 15 Feb 2026 | 4 articles | Viewed by 15977 | Submission Open

Keywords: PD-1 immune checkpoint; CAR-T cells; γ δ T cells; NK cells

(This special issue belongs to the Section Cellular Immunology)

State-of-the-Art Research on Histone Deacetylases (HDACs) and Histone Acetyltransferases (HATs)

edited by

Xiaohong Zhang

submission deadline 15 Feb 2026 | 4 articles | Viewed by 12440 | Submission Open

Keywords: histone deacetylases; cancer; metabolism; immunotherapy; tumor microenvironment; DNA damage response; cell cycle

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Molecular Therapeutic Advances for Neurodegenerative Diseases

edited by

Vanessa Castelli

submission deadline 15 Feb 2026 | 3 articles | Viewed by 6783 | Submission Open

Keywords: neurodegenerative diseases; neurodegeneration; neurological disorders

(This special issue belongs to the Section Cellular Aging)

Spotlight on Natural Killer Cells in Immuno-Oncology

edited by

Anahid Jewett

and

Kawaljit Kaur

submission deadline 15 Feb 2026 | 1 articles | Viewed by 4183 | Submission Open

Keywords: natural killer (NK) cells; cancer stem cells (CSCs); poorly differentiated tumors; differentiation; aggressive tumors; suppressor cells

(This special issue belongs to the Section Cellular Immunology)

Epigenetic Mechanisms of Tumorigenesis

edited by

Hengbin Wang

submission deadline 15 Feb 2026 | 1 articles | Viewed by 2288 | Submission Open

Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine

Cancers and Metabolic Diseases—the Molecular Players in the Game

edited by

T.K.S. Kumar

submission deadline 15 Feb 2026 | Viewed by 195 | Submission Open

Keywords: metabolism; bioenergetics; signaling; cytokines; molecular; mechanisms; receptors; design; therapeutics

GPCR Signaling in PDA: Calcium, cAMP, and Ras Activation in Pancreatic Ductal Adenocarcinoma

edited by

Thomas Wilkie

submission deadline 15 Feb 2026 | Viewed by 172 | Submission Open

Keywords: G protein-coupled receptor (GPCR); receptor tyrosine kinases (RTK); oncogenic Kras; pancreatic ductal adenocarcinoma (PDA); epigenetic regulation; Wnt and Hedgehog (HH); second messengers (cAMP and intracellular calcium); acinar to ductal metaplasia (ADM); tumor microenvironment; therapeutic drugs list of solicited contributors

Cellular Mechanisms and Therapies of Hematologic Malignancies

edited by Sayantani Sinha and Stanley Chun-Wei Lee

submission deadline 15 Feb 2026 | Viewed by 141 | Submission Open

Keywords: AML; ALL and CLL; targeted therapy; combination therapy; small molecule inhibitors; immunotherapy; RNA in hematopoiesis; overcoming resistance

(This special issue belongs to the Section Cellular Pathology)

Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease

edited by

Paul M. Epstein

Stefan Brocke

, Michy P. Kelly and Leila Gobejishvili

submission deadline 20 Feb 2026 | 17 articles | Viewed by 60004 | Submission Open

Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction

(This special issue belongs to the Section Cell Microenvironment)

Motor Neuron Diseases: From Molecular Basic Research to Diagnosis and Therapeutics Implications

edited by

Ilaria Martinelli

and Elisabetta Zucchi

submission deadline 20 Feb 2026 | 5 articles | Viewed by 14520 | Submission Open

Keywords: motor neuron; genetics; oxidative stress; misfolded protein aggregates; biomarkers; gene therapy

(This special issue belongs to the Section Cellular Neuroscience)

Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth

edited by Khondoker M. Akram

submission deadline 20 Feb 2026 | 3 articles | Viewed by 9365 | Submission Open

Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth

(This special issue belongs to the Section Cellular Pathology)

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