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Journals
Chemosensors
Special Issues
Enzyme-Based Sensing Approaches
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Enzyme-Based Sensing Approaches

A special issue of Chemosensors (ISSN 2227-9040).

Deadline for manuscript submissions: closed (31 October 2018) | Viewed by 3833

Special Issue Editor

Dr. Jan Halámek

E-Mail Website
Guest Editor
State University of New York, University at Albany, Dept. of Chemistry, Albany, USA
Interests: bioaffinity; sensing; metabolite; forensics; biometrics; non-invasive; on-field diagnostics

Special Issue Information

Dear Colleagues,

Enzymatic sensors have been studied for many years now, but very few applications are currently available to the public. The most well-known utilization of enzymatic sensors to date is the glucometer that was developed over 40 years ago. This invention revolutionized the medical field and has shown the great potential of these sensor applications. Enzymatic sensors, however, are not limited to only the medical field. These sensors can be adapted in a myriad of areas including forensics, cyber security, and health monitoring. The specific nature of the bonds used in enzymatic sensor systems produces highly sensitive and reproducible results in short amounts of time with an extremely small amount of materials. Recent demand for enzymatic sensor systems has grown due to their great versatility, speed, ease of use, and cost efficiency.

This Special Issue on enzymatic sensors will present the newest applications and latest advances in enzymatic sensor systems and technology that utilizes these systems. Articles will range anywhere from healthcare and health monitoring to forensics and defense.

Dr. Jan Halámek
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • enzyme
  • bioaffinity
  • biorecognition
  • sensing
  • receptor

Published Papers (1 paper)

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Research

15 pages, 1451 KiB  
Article
Propylene Glycol Stabilizes the Linear Response of Glutamate Biosensor: Potential Implications for In-Vivo Neurochemical Monitoring
by Gaia Rocchitta, Andrea Bacciu, Paola Arrigo, Rossana Migheli, Gianfranco Bazzu and Pier Andrea Serra
Chemosensors 2018, 6(4), 58; https://doi.org/10.3390/chemosensors6040058 - 28 Nov 2018
Cited by 9 | Viewed by 3521
Abstract
L-glutamate is one the most important excitatory neurotransmitter at the central nervous system level and it is implicated in several pathologies. So, it is very important to monitor its variations, in real time in animal models’ brain. The present study aimed to develop [...] Read more.
L-glutamate is one the most important excitatory neurotransmitter at the central nervous system level and it is implicated in several pathologies. So, it is very important to monitor its variations, in real time in animal models’ brain. The present study aimed to develop and characterize a new amperometric glutamate biosensor design that exploits the selectivity of Glutamate Oxidase (GluOx) for l-glutamate, and the capability of a small molecule as propylene glycol (PG), never used before, to influence and extend the stability and the activity of enzyme. Different designs were evaluated by modifying the main components in their concentrations to find the most suitable design. Moreover, enzyme concentrations from 100 U/mL up to 200 U/mL were verified and different PG concentrations (1%, 0.1% and 0.05%) were tested. The most suitable selected design was Ptc/PPD/PEI(1%)2/GlutOx5/PG(0.1%) and it was compared to the same already described design loading PEDGE, instead of PG, in terms of over-time performances. The PG has proved to be capable of determining an over-time stability of the glutamate biosensor in particular in terms of linear region slope (LRS) up to 21 days. Full article
(This article belongs to the Special Issue Enzyme-Based Sensing Approaches)
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